PMID- 24620726
OWN - NLM
STAT- MEDLINE
DCOM- 20150223
LR  - 20151119
IS  - 1473-7760 (Electronic)
IS  - 1052-0295 (Linking)
VI  - 89
IP  - 5
DP  - 2014 Jul
TI  - The effects of L-carnitine on some hematological parameters in rats fed a 
      cholesterol-rich diet.
PG  - 393-7
LID - 10.3109/10520295.2014.892153 [doi]
AB  - We evaluated the effects of L-carnitine on the hematological characteristics of 
      rats fed a cholesterol-rich diet. Healthy male Wistar Albino rats were assigned 
      to four equal groups. During the 40 day experiment, group 1 was fed standard rat 
      pellets, group 2 was fed standard rat pellets containing 7.5 % cholesterol 
      powder, group 3 was fed standard rat pellets and water that contained 75 mg/l 
      L-carnitine, and group 4 was fed standard rat pellets that contained 7.5% 
      cholesterol and water that contained 75 mg/l L-carnitine. Blood samples were 
      analyzed for red (RBC) and white (WBC) blood cells, hemoglobin, hematocrit, 
      granulocytes, lymphocytes, monocytes, mean cell volume (MCV), mean corpuscular 
      hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) using an 
      automated cell counter. The RBC count in the group that received the 7.5% 
      cholesterol diet was decreased significantly compared to the other groups. The 
      hematocrit of the cholesterol group was lower than for the L-carnitine + 
      cholesterol and L-carnitine groups. The MCV in the cholesterol group was 
      significantly higher than the control group. The MCH in the cholesterol group was 
      higher than for the other groups. There was no significant difference among the 
      groups with regard to hemoglobin, MCHC, WBCs and leukocyte types. L-carnitine 
      appears to have beneficial effects on erythrocyte stability, erythropoiesis and 
      hyperlipidemia.
FAU - Uluisik, D
AU  - Uluisik D
AD  - Department of Physiology, Faculty of Veterinary Medicine, University of Selcuk , 
      Konya , Turkey.
FAU - Keskin, E
AU  - Keskin E
LA  - eng
PT  - Journal Article
DEP - 20140312
PL  - England
TA  - Biotech Histochem
JT  - Biotechnic & histochemistry : official publication of the Biological Stain 
      Commission
JID - 9107378
RN  - 0 (Cholesterol, Dietary)
RN  - S7UI8SM58A (Carnitine)
SB  - IM
MH  - Animals
MH  - Blood Chemical Analysis
MH  - Carnitine/*pharmacology
MH  - Cholesterol, Dietary/*blood
MH  - Erythrocyte Count
MH  - Erythrocyte Indices/*drug effects
MH  - Erythrocytes/*drug effects
MH  - Hematocrit
MH  - Leukocyte Count
MH  - Leukocytes/drug effects
MH  - Male
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - L-carnitine
OT  - cholesterol
OT  - hematological characteristics
OT  - rats
EDAT- 2014/03/14 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/03/14 06:00
PHST- 2014/03/14 06:00 [entrez]
PHST- 2014/03/14 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - 10.3109/10520295.2014.892153 [doi]
PST - ppublish
SO  - Biotech Histochem. 2014 Jul;89(5):393-7. doi: 10.3109/10520295.2014.892153. Epub 
      2014 Mar 12.