PMID- 24620898
OWN - NLM
STAT- MEDLINE
DCOM- 20151021
LR  - 20211021
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Print)
IS  - 1355-6215 (Linking)
VI  - 20
IP  - 2
DP  - 2015 Mar
TI  - Dorsal medial prefrontal cortex (MPFC) circuitry in rodent models of cocaine use: 
      implications for drug addiction therapies.
PG  - 215-26
LID - 10.1111/adb.12132 [doi]
AB  - Although the importance of the medial prefrontal cortex (MPFC) in cocaine 
      addiction is well established, its precise contribution to cocaine seeking, 
      taking and relapse remains incompletely understood. In particular, across two 
      different models of cocaine self-administration, pharmacological or optogenetic 
      activation of the dorsal MPFC has been reported to sometimes promote and 
      sometimes inhibit cocaine seeking. We highlight important methodological 
      differences between the two experimental paradigms and propose a framework to 
      potentially reconcile the apparent discrepancy. We also draw parallels between 
      these pre-clinical models of cocaine self-administration and human neuro-imaging 
      studies in cocaine users, and argue that both lines of evidence point to dynamic 
      interactions between cue-reactivity processes and control processes within the 
      dorsal MPFC circuitry. From a translational perspective, these findings 
      underscore the importance of interventions and therapeutics targeting not just a 
      brain region, but a specific computational process within that brain region, and 
      may have implications for the design and implementation of more effective 
      treatments for human cocaine addiction.
CI  - Published 2014. This article is a U.S. Government work and is in the public 
      domain in the USA.
FAU - Jasinska, Agnes J
AU  - Jasinska AJ
AD  - Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, 
      USA.
FAU - Chen, Billy T
AU  - Chen BT
FAU - Bonci, Antonello
AU  - Bonci A
FAU - Stein, Elliot A
AU  - Stein EA
LA  - eng
GR  - Z99 DA999999/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20140313
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
SB  - IM
MH  - Animals
MH  - Brain/physiopathology
MH  - Cocaine-Related Disorders/*physiopathology
MH  - Disease Models, Animal
MH  - Humans
MH  - Prefrontal Cortex/*physiopathology
MH  - Rats
MH  - Self Administration
PMC - PMC4163139
MID - NIHMS571091
OTO - NOTNLM
OT  - Addiction
OT  - cocaine
OT  - medial prefrontal cortex
OT  - prelimbic cortex
EDAT- 2014/03/14 06:00
MHDA- 2015/10/22 06:00
PMCR- 2016/03/01
CRDT- 2014/03/14 06:00
PHST- 2014/03/14 06:00 [entrez]
PHST- 2014/03/14 06:00 [pubmed]
PHST- 2015/10/22 06:00 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - 10.1111/adb.12132 [doi]
PST - ppublish
SO  - Addict Biol. 2015 Mar;20(2):215-26. doi: 10.1111/adb.12132. Epub 2014 Mar 13.