PMID- 24621058
OWN - NLM
STAT- MEDLINE
DCOM- 20150122
LR  - 20140521
IS  - 1476-8305 (Electronic)
IS  - 1028-415X (Linking)
VI  - 17
IP  - 4
DP  - 2014 Jul
TI  - Dietary omega-3 deficiency reduces BDNF content and activation NMDA receptor and 
      Fyn in dorsal hippocampus: implications on persistence of long-term memory in 
      rats.
PG  - 186-92
LID - 10.1179/1476830513Y.0000000087 [doi]
AB  - Omega-3 (n-3) fatty acids are important for adequate brain function and 
      cognition. The aim of the present study was to evaluate how n-3 fatty acids 
      influence the persistence of long-term memory (LTM) in an aversive memory task 
      and to explore the putative mechanism involved. Female rats received isocaloric 
      diets that included n-3 (n-3 group) or not (D group). The adult litters were 
      subjected to an inhibitory avoidance task (0.7 mA, 1.0 seconds foot shock) to 
      elicit persistent LTM. Twelve hours after the training session, the fatty acid 
      profile and the brain derived neurotrophic factor (BDNF) content of the dorsal 
      hippocampus were assessed. In addition, we measured the activation of the NR2B 
      subunit of the N-methyl-d-aspartate (NMDA) receptor and the SRC family protein 
      Fyn. Despite pronounced learning in both groups, the persistence of LTM was 
      abolished in the D group 7 days after the training session. We also observed that 
      the D group presented reductions in hippocampal DHA (22:6 n-3) and BDNF content. 
      Twelve hours after the training session, the D group showed decreased NR2B and 
      Fyn phosphorylation in the dorsal hippocampus, with no change in the total 
      content of these proteins. Further, there was a decrease in the interaction of 
      Fyn with NR2B in the D group, as observed by co-immunoprecipitation. Taken 
      together, these data suggest that n-3 fatty acids influence the persistence of 
      LTM by maintaining adequate levels of DHA and BDNF as well as by influencing the 
      activation of NR2B and Fyn during the period of memory formation.
FAU - Bach, Simone Azevedo
AU  - Bach SA
FAU - de Siqueira, Leticia V
AU  - de Siqueira LV
FAU - Muller, Alexandre P
AU  - Muller AP
FAU - Oses, Jean P
AU  - Oses JP
FAU - Quatrim, Andreia
AU  - Quatrim A
FAU - Emanuelli, Tatiana
AU  - Emanuelli T
FAU - Vinade, Lucia
AU  - Vinade L
FAU - Souza, Diogo O
AU  - Souza DO
FAU - Moreira, Julia D
AU  - Moreira JD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131126
PL  - England
TA  - Nutr Neurosci
JT  - Nutritional neuroscience
JID - 100892202
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - EC 2.7.10.2 (Fyn protein, rat)
RN  - EC 2.7.10.2 (Proto-Oncogene Proteins c-fyn)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*drug effects
MH  - Docosahexaenoic Acids/metabolism
MH  - Fatty Acids, Omega-3/administration & dosage/*blood
MH  - Fatty Acids, Unsaturated/deficiency
MH  - Female
MH  - Hippocampus/drug effects/metabolism
MH  - Learning/drug effects
MH  - Memory/drug effects
MH  - Memory, Long-Term/*drug effects
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins c-fyn/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Fyn
OT  - LTM
OT  - Memory
OT  - NMDA receptor
OT  - n-3 Fatty acids
EDAT- 2014/03/14 06:00
MHDA- 2015/01/23 06:00
CRDT- 2014/03/14 06:00
PHST- 2014/03/14 06:00 [entrez]
PHST- 2014/03/14 06:00 [pubmed]
PHST- 2015/01/23 06:00 [medline]
AID - 10.1179/1476830513Y.0000000087 [doi]
PST - ppublish
SO  - Nutr Neurosci. 2014 Jul;17(4):186-92. doi: 10.1179/1476830513Y.0000000087. Epub 
      2013 Nov 26.