PMID- 24621474
OWN - NLM
STAT- MEDLINE
DCOM- 20150419
LR  - 20151119
IS  - 1348-4214 (Electronic)
IS  - 0916-9636 (Linking)
VI  - 37
IP  - 8
DP  - 2014 Aug
TI  - The six-minute walk distance is a marker of hemodynamic-related functional 
      capacity in hypertension: a case-control study.
PG  - 746-52
LID - 10.1038/hr.2014.59 [doi]
AB  - This study investigated the association between hemodynamic variables and the 
      6-minute walk distance (6MWD) in adults with and without hypertension and 
      explored the role of hemodynamic variables as predictors of 6MWD. Patients 
      undergoing antihypertensive medication therapy (n=41) and sex-matched healthy 
      subjects (n=41) were evaluated for their clinical status and cardiovascular risk 
      factors. Two 6-minute walk tests were performed along an 18-m corridor with a 
      30-minute rest interval. The intraclass correlation (ICC) was high among patients 
      (ICC=0.984 (0.965; 0.992), P<0.001) and controls (ICC=0.987 (0.832; 0.996), 
      P<0.001). The patients presented 6MWD values that were significantly lower than 
      those of healthy controls (338.8+/-112.8 vs. 388.0+/-66.7 m, P=0.010). In patients, 
      the 6MWD was significantly and positively correlated with sex (0.737; P<0.001), 
      height (0.502; P<0.001) and weight (0.303; P=0.027). In addition, negative and 
      significant correlations were observed between 6MWD and the mean (-0.577; 
      P<0.001), systolic (-0.521; P<0.001), diastolic (-0.505; P=0.001) and pulse 
      (-0.353; P=0.015) pressures after simultaneous adjustment for age, body height 
      and weight. The same behavior was observed in healthy controls (except for pulse 
      pressure), albeit with lower correlation values. A regression model with sex, 
      age, height and weight explained 52.2% (P<0.001) of the variance. The highest 
      explained variance in patients (64.8%; P<0.001) and controls (56.5%; P<0.001) was 
      observed after replacing the body weight with mean pressure in the model. The 
      6MWD is inversely associated with hemodynamic variables in both groups and is 
      lower in patients with hypertension compared with healthy controls. Hemodynamic 
      variables, particularly the mean pressure, should be included in prediction 
      equations for 6MWD.
FAU - Ramos, Rodrigo A
AU  - Ramos RA
AD  - Postgraduate Program of Rehabilitation Science, Centro Universitario Augusto 
      Motta/UNISUAM, Rio de Janeiro, Brazil.
FAU - Guimaraes, Fernando S
AU  - Guimaraes FS
AD  - Postgraduate Program of Rehabilitation Science, Centro Universitario Augusto 
      Motta/UNISUAM, Rio de Janeiro, Brazil.
FAU - Cordovil, Ivan
AU  - Cordovil I
AD  - Division of Arterial Hypertension, National Institute of Cardiology/MS, Rio de 
      Janeiro, Brazil.
FAU - de Sa Ferreira, Arthur
AU  - de Sa Ferreira A
AD  - Postgraduate Program of Rehabilitation Science, Centro Universitario Augusto 
      Motta/UNISUAM, Rio de Janeiro, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140313
PL  - England
TA  - Hypertens Res
JT  - Hypertension research : official journal of the Japanese Society of Hypertension
JID - 9307690
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - *Biomarkers
MH  - Blood Pressure/physiology
MH  - Case-Control Studies
MH  - Female
MH  - Heart Rate/physiology
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Hypertension/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Walking/*physiology
EDAT- 2014/03/14 06:00
MHDA- 2015/04/22 06:00
CRDT- 2014/03/14 06:00
PHST- 2013/10/16 00:00 [received]
PHST- 2013/12/01 00:00 [revised]
PHST- 2014/01/05 00:00 [accepted]
PHST- 2014/03/14 06:00 [entrez]
PHST- 2014/03/14 06:00 [pubmed]
PHST- 2015/04/22 06:00 [medline]
AID - hr201459 [pii]
AID - 10.1038/hr.2014.59 [doi]
PST - ppublish
SO  - Hypertens Res. 2014 Aug;37(8):746-52. doi: 10.1038/hr.2014.59. Epub 2014 Mar 13.