PMID- 24621946
OWN - NLM
STAT- MEDLINE
DCOM- 20150417
LR  - 20150221
IS  - 1758-535X (Electronic)
IS  - 1079-5006 (Linking)
VI  - 70
IP  - 3
DP  - 2015 Mar
TI  - Brain-derived neurotrophic factor plasma levels: relationship with dementia and 
      diabetes in the elderly population.
PG  - 294-302
LID - 10.1093/gerona/glu028 [doi]
AB  - The mechanisms linking diabetes and cognitive impairment/dementia, two common 
      conditions of elderly people, are not completely known. Brain-derived 
      neurotrophic factor (BDNF) has antidiabetic properties, and reduced circulating 
      BDNF was associated with dementia. We investigated the relationship between 
      plasma BDNF levels, dementia, and diabetes in a sample of 164 community-dwelling 
      elderly individuals, including 50 participants with vascular dementia, 44 with 
      late onset Alzheimer's disease, 23 with cerebrovascular disease not dementia, and 
      47 controls (C). Presence/absence of diabetes was registered; new diagnoses of 
      diabetes were made by the American Diabetes Association criteria. BDNF plasma 
      levels were measured by ELISA. Both diagnosis of dementia and diabetes were 
      associated with lower BDNF plasma values compared with the respective controls; 
      moreover, dementia and diabetes correlated with BDNF plasma levels, independent 
      of possible confounders. A progressive reductions of BDNF plasma levels from C 
      (383.9 +/- 204.6 pg/mL), to cerebrovascular disease not dementia (377.1 +/- 130.2), 
      to vascular dementia (313.3 +/- 114.8), to late onset Alzheimer's disease (264.7 +/- 
      147.7) was observed, (late onset Alzheimer's disease vs C, p: .03; late onset 
      Alzheimer's disease vs cerebrovascular disease not dementia, p: .002). Demented 
      patients affected by diabetes had the lowest BDNF mean levels (264.9 pg/mL) among 
      individuals enrolled in this sample, suggesting the existence of a "synergistic" 
      effect of dementia and diabetes on BDNF levels.
CI  - (c) The Author 2014. Published by Oxford University Press on behalf of The 
      Gerontological Society of America. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Passaro, Angela
AU  - Passaro A
AD  - Department of Clinical and Experimental Medicine, Section of Internal Medicine, 
      Gerontology and Clinical Nutrition, University of Ferrara, Italy.
FAU - Dalla Nora, Edoardo
AU  - Dalla Nora E
AD  - Department of Clinical and Experimental Medicine, Section of Internal Medicine, 
      Gerontology and Clinical Nutrition, University of Ferrara, Italy.
FAU - Morieri, Mario L
AU  - Morieri ML
AD  - Department of Clinical and Experimental Medicine, Section of Internal Medicine, 
      Gerontology and Clinical Nutrition, University of Ferrara, Italy.
FAU - Soavi, Cecilia
AU  - Soavi C
AD  - Department of Clinical and Experimental Medicine, Section of Internal Medicine, 
      Gerontology and Clinical Nutrition, University of Ferrara, Italy.
FAU - Sanz, Juana M
AU  - Sanz JM
AD  - Department of Clinical and Experimental Medicine, Section of Internal Medicine, 
      Gerontology and Clinical Nutrition, University of Ferrara, Italy.
FAU - Zurlo, Amedeo
AU  - Zurlo A
AD  - Operative Unit of Geriatrics, Arcispedale S. Anna, Ferrara, Italy.
FAU - Fellin, Renato
AU  - Fellin R
AD  - Department of Clinical and Experimental Medicine, Section of Internal Medicine, 
      Gerontology and Clinical Nutrition, University of Ferrara, Italy.
FAU - Zuliani, Giovanni
AU  - Zuliani G
AD  - Department of Clinical and Experimental Medicine, Section of Internal Medicine, 
      Gerontology and Clinical Nutrition, University of Ferrara, Italy. 
      gzuliani@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20140312
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*blood/complications/diagnosis
MH  - Blood Pressure
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Cholesterol/blood
MH  - Dementia, Vascular/*blood/complications/diagnosis
MH  - Diabetes Complications/*blood/diagnosis/*psychology
MH  - Female
MH  - Humans
MH  - Male
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - BDNF
OT  - Dementia
OT  - Diabetes
OT  - Elderly individuals.
EDAT- 2014/03/14 06:00
MHDA- 2015/04/18 06:00
CRDT- 2014/03/14 06:00
PHST- 2014/03/14 06:00 [entrez]
PHST- 2014/03/14 06:00 [pubmed]
PHST- 2015/04/18 06:00 [medline]
AID - glu028 [pii]
AID - 10.1093/gerona/glu028 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2015 Mar;70(3):294-302. doi: 
      10.1093/gerona/glu028. Epub 2014 Mar 12.