PMID- 24622390
OWN - NLM
STAT- MEDLINE
DCOM- 20150529
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 3
DP  - 2014
TI  - Oral Chinese herbal medicine combined with pharmacotherapy for stable COPD: a 
      systematic review of effect on BODE index and six minute walk test.
PG  - e91830
LID - 10.1371/journal.pone.0091830 [doi]
LID - e91830
AB  - This systematic review evaluated the effects of Chinese herbal medicine (CHM) 
      plus routine pharmacotherapy (RP) on the objective outcome measures BODE index, 
      6-minute walk test (6MWT), and 6-minute walk distance (6MWD) in individuals with 
      stable chronic obstructive pulmonary disease (COPD). Searches were conducted of 
      six English and Chinese databases (PubMed, EMBASE, CENTRAL, CINAHL, CNKI and 
      CQVIP) from their inceptions until 18th November 2013 for randomized controlled 
      trials involving oral administration of CHM plus RP compared to the same RP, with 
      BODE Index and/or 6MWT/D as outcomes. Twenty-five studies were identified. BODE 
      Index was used in nine studies and 6MWT/D was used in 22 studies. Methodological 
      quality was assessed using the Cochrane Risk of Bias tool. Weaknesses were 
      identified in most studies. Six studies were judged as 'low' risk of bias for 
      randomisation sequence generation. Twenty-two studies involving 1,834 
      participants were included in the meta-analyses. The main meta-analysis results 
      showed relative benefits for BODE Index in nine studies (mean difference [MD] 
      -0.71, 95% confidence interval [CI] -0.94, -0.47) and 6MWT/D in 17 studies (MD 
      54.61 meters, 95%CI 33.30, 75.92) in favour of the CHM plus RP groups. The 
      principal plants used were Astragalus membranaceus, Panax ginseng and Cordyceps 
      sinensis. A. membranaceus was used in combination with other herbs in 18 formulae 
      in 16 studies. Detailed sub-group and sensitivity analyses were conducted. 
      Clinically meaningful benefits for BODE Index and 6MWT were found in multiple 
      studies. These therapeutic effects were promising but need to be interpreted with 
      caution due to variations in the CHMs and RPs used and methodological weakness in 
      the studies. These issues should be addressed in future trials.
FAU - Chen, Xiankun
AU  - Chen X
AD  - Evidence-Based Medicine & Clinical Research Service Group, Guangdong Provincial 
      Academy of Chinese Medical Sciences, Guangzhou, China; Guangdong Provincial 
      Hospital of Chinese Medicine, Guangzhou, China.
FAU - May, Brian
AU  - May B
AD  - Traditional & Complementary Medicine Research Program, Health Innovations 
      Research Institute, School of Health Sciences, RMIT University, Melbourne, 
      Australia.
FAU - Di, Yuan Ming
AU  - Di YM
AD  - Traditional & Complementary Medicine Research Program, Health Innovations 
      Research Institute, School of Health Sciences, RMIT University, Melbourne, 
      Australia.
FAU - Zhang, Anthony Lin
AU  - Zhang AL
AD  - Traditional & Complementary Medicine Research Program, Health Innovations 
      Research Institute, School of Health Sciences, RMIT University, Melbourne, 
      Australia.
FAU - Lu, Chuanjian
AU  - Lu C
AD  - Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China; Guangdong 
      Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
FAU - Xue, Charlie Changli
AU  - Xue CC
AD  - Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China; Traditional 
      & Complementary Medicine Research Program, Health Innovations Research Institute, 
      School of Health Sciences, RMIT University, Melbourne, Australia; Guangdong 
      Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
FAU - Lin, Lin
AU  - Lin L
AD  - Department of Respiratory Medicine, Guangdong Provincial Hospital of Chinese 
      Medicine, Guangzhou, Guangdong Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20140312
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Administration, Oral
MH  - Drug Interactions
MH  - Drugs, Chinese Herbal/*administration & dosage/*pharmacology/therapeutic use
MH  - *Exercise Test
MH  - Humans
MH  - Pulmonary Disease, Chronic Obstructive/diagnosis/*drug therapy/physiopathology
MH  - Time Factors
MH  - *Walking
PMC - PMC3951501
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/03/14 06:00
MHDA- 2015/05/30 06:00
PMCR- 2014/03/12
CRDT- 2014/03/14 06:00
PHST- 2013/08/22 00:00 [received]
PHST- 2014/02/15 00:00 [accepted]
PHST- 2014/03/14 06:00 [entrez]
PHST- 2014/03/14 06:00 [pubmed]
PHST- 2015/05/30 06:00 [medline]
PHST- 2014/03/12 00:00 [pmc-release]
AID - PONE-D-13-36785 [pii]
AID - 10.1371/journal.pone.0091830 [doi]
PST - epublish
SO  - PLoS One. 2014 Mar 12;9(3):e91830. doi: 10.1371/journal.pone.0091830. eCollection 
      2014.