PMID- 24622829
OWN - NLM
STAT- MEDLINE
DCOM- 20141113
LR  - 20181202
IS  - 1899-1505 (Electronic)
IS  - 0867-5910 (Linking)
VI  - 65
IP  - 1
DP  - 2014 Feb
TI  - Effect of dehydroepiandrosterone (DHEA) on memory and brain derived neurotrophic 
      factor (BDNF) in a rat model of vascular dementia.
PG  - 41-53
AB  - The effect of dehydroepiandrosterone (DHEA) on memory and cognition in 
      experimental animals is well known, but its efficacy in clinical dementia is 
      unproven. So, the aim of the present study was to investigate the effect of DHEA 
      on learning and memory activities in a rat model of vascular dementia (VD). 
      Forty-eight male rats that positively passed the holeboard memory test were 
      chosen for the study before bilateral permanent occlusion of the common carotid 
      artery. They were divided into four groups (n=12, each) as follows (i) untreated 
      control, (ii) rats exposed to surgical permanent bilateral occlusion of the 
      common carotid arteries (BCCAO) leading to chronic cerebral hypoperfusion, (iii) 
      rats exposed to BCCAO then received DHEA (BCCAO + DHEA) and (i.v.) rats exposed 
      to BCCAO then received donepezil (BCCAO + DON). Holeboard memory test was used to 
      assess the time, latency, working memory and reference memory. Central level of 
      acetylcholine, norepinephrine and dopamine in the hippocampus were measured. 
      Furthermore, the expression of brain derived neurotrophic factor (BDNF) in the 
      hippocampus was determined. Histopathological studies of the cerebral cortex and 
      transmission electron microscope of the hippocampus were performed. BCCAO 
      decreased the learning and memory activities in the holeboard memory. Also, it 
      decreased the expression of BDNF as well as the central level of acetylcholine, 
      noradrenaline and dopamine as compared to control rats. Treatment with DHEA and 
      donepezil increased the working and reference memories, BDNF expression as well 
      as the central acetylcholine in the hippocampus as compared to BCCAO rats. DHEA 
      produced neuroprotective effects through increasing the expression of BDNF as 
      well as increasing the central level of acetylcholine and catecholamines which 
      are non-comparable to donepezil effects.
FAU - Sakr, H F
AU  - Sakr HF
AD  - Medical Physiology Department, Faculty of Medicine, Mansoura University, 
      Mansoura, Egypt. sakr_doctor@yahoo.com.
FAU - Khalil, K I
AU  - Khalil KI
FAU - Hussein, A M
AU  - Hussein AM
FAU - Zaki, M S A
AU  - Zaki MS
FAU - Eid, R A
AU  - Eid RA
FAU - Alkhateeb, M
AU  - Alkhateeb M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - J Physiol Pharmacol
JT  - Journal of physiology and pharmacology : an official journal of the Polish 
      Physiological Society
JID - 9114501
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Indans)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Piperidines)
RN  - 459AG36T1B (Dehydroepiandrosterone)
RN  - 8SSC91326P (Donepezil)
RN  - N9YNS0M02X (Acetylcholine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Carotid Artery, Common/surgery
MH  - Dehydroepiandrosterone/*pharmacology
MH  - Dementia, Vascular/*metabolism/pathology
MH  - Donepezil
MH  - Dopamine/metabolism
MH  - Hippocampus/drug effects/metabolism/pathology
MH  - Indans/pharmacology
MH  - Male
MH  - Memory/*drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Neuropsychological Tests
MH  - Norepinephrine/metabolism
MH  - Piperidines/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2014/03/14 06:00
MHDA- 2014/11/14 06:00
CRDT- 2014/03/14 06:00
PHST- 2013/09/30 00:00 [received]
PHST- 2014/01/07 00:00 [accepted]
PHST- 2014/03/14 06:00 [entrez]
PHST- 2014/03/14 06:00 [pubmed]
PHST- 2014/11/14 06:00 [medline]
PST - ppublish
SO  - J Physiol Pharmacol. 2014 Feb;65(1):41-53.