PMID- 24623376
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20211021
IS  - 1757-4684 (Electronic)
IS  - 1757-4676 (Print)
IS  - 1757-4676 (Linking)
VI  - 6
IP  - 5
DP  - 2014 May
TI  - Mitochondrial response to nutrient availability and its role in metabolic 
      disease.
PG  - 580-9
LID - 10.1002/emmm.201303782 [doi]
AB  - Metabolic inflexibility is defined as an impaired capacity to switch between 
      different energy substrates and is a hallmark of insulin resistance and type 2 
      diabetes mellitus (T2DM). Hence, understanding the mechanisms underlying proper 
      metabolic flexibility is key to prevent the development of metabolic disease and 
      physiological deterioration. An important downstream player in the effects of 
      metabolic flexibility is the mitochondrion. The objective of this review was to 
      describe how mitochondrial metabolism adapts to limited nutrient situations or 
      caloric excess by changes in mitochondrial function or biogenesis, as well as to 
      define the mechanisms propelling these changes. Altogether, this should pinpoint 
      key regulatory points by which metabolic flexibility might be ameliorated in 
      situations of metabolic disease.
FAU - Gao, Arwen W
AU  - Gao AW
AD  - Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, The 
      Netherlands.
FAU - Canto, Carles
AU  - Canto C
FAU - Houtkooper, Riekelt H
AU  - Houtkooper RH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - EMBO Mol Med
JT  - EMBO molecular medicine
JID - 101487380
SB  - IM
MH  - *Adaptation, Physiological
MH  - *Food
MH  - Humans
MH  - Metabolic Diseases/*physiopathology
MH  - Mitochondria/metabolism/*physiology
PMC - PMC4023882
EDAT- 2014/03/14 06:00
MHDA- 2014/12/23 06:00
PMCR- 2014/05/01
CRDT- 2014/03/14 06:00
PHST- 2014/03/14 06:00 [entrez]
PHST- 2014/03/14 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - emmm.201303782 [pii]
AID - 10.1002/emmm.201303782 [doi]
PST - ppublish
SO  - EMBO Mol Med. 2014 May;6(5):580-9. doi: 10.1002/emmm.201303782.