PMID- 2462345
OWN - NLM
STAT- MEDLINE
DCOM- 19890125
LR  - 20190626
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 85
IP  - 6A
DP  - 1988 Dec 23
TI  - Structural and genetic features of human leukocytic antigen class II elements 
      associated with rheumatoid arthritis.
PG  - 12-3
AB  - Analysis of individual human leukocyte antigen (HLA) genes associated with 
      rheumatoid arthritis was performed using oligonucleotide probes to identify 
      putative susceptibility genes highly associated with disease. Among DR4-positive 
      rheumatoid arthritis patients, two distinct DR-beta genes, Dw4 and Dw14, appear 
      to be individual susceptibility alleles. Linked HLA genes at the DQ locus do not 
      appear to contribute to this genetic risk. Among non-DR4 rheumatoid arthritis 
      patients, a specific DNA sequence was identified that is shared by the Dw14 
      susceptibility gene and a majority of the non-DR4 rheumatoid arthritis patients. 
      This sequence defines a specific small genetic element encoding a "Dw14 epitope" 
      that appears to be a rheumatoid arthritis-associated risk factor indicative of a 
      common genetic pathway in both DR4 and non-DR4-associated disease.
FAU - Nepom, G T
AU  - Nepom GT
AD  - Virginia Mason Research Center, Seattle, Washington, Immunology Research Program 
      98101.
LA  - eng
GR  - AR 37296/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Epitopes)
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Arthritis, Rheumatoid/*genetics
MH  - Epitopes/genetics
MH  - Genetic Linkage
MH  - Genetic Predisposition to Disease
MH  - HLA-D Antigens/*genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - Humans
RF  - 17
EDAT- 1988/12/23 00:00
MHDA- 1988/12/23 00:01
CRDT- 1988/12/23 00:00
PHST- 1988/12/23 00:00 [pubmed]
PHST- 1988/12/23 00:01 [medline]
PHST- 1988/12/23 00:00 [entrez]
AID - 0002-9343(88)90372-5 [pii]
AID - 10.1016/0002-9343(88)90372-5 [doi]
PST - ppublish
SO  - Am J Med. 1988 Dec 23;85(6A):12-3. doi: 10.1016/0002-9343(88)90372-5.