PMID- 2462346
OWN - NLM
STAT- MEDLINE
DCOM- 19890125
LR  - 20190626
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 85
IP  - 6A
DP  - 1988 Dec 23
TI  - Function and polymorphism of human leukocyte antigen-A,B,C molecules.
PG  - 2-5
AB  - Human class I major histocompatibility complex, human leukocyte antigen 
      (HLA)-A,B,C molecules are peptide-binding proteins that present degraded 
      fragments of antigens to cytotoxic T lymphocytes. HLA-A,B,C loci are highly 
      polymorphic and their products are strong alloantigens. Comparison of the primary 
      structure of 39 HLA-A,B,C molecules shows that variation is found at many 
      positions in the extracellular domains (alpha 1, alpha 2, and alpha 3). Positions 
      with high variability are concentrated in and around the peptide-binding groove 
      formed by the alpha 1- and alpha 2-domains and defined by crystallographic 
      analysis of HLA-A2. It is likely that the polymorphic differences serve to alter 
      both the peptide-binding specificity and the interaction with T cell receptors. 
      This in turn may result in differences in immune responsiveness, susceptibility, 
      and resistance to disease, and in alloantigenicity.
FAU - Parham, P
AU  - Parham P
AD  - Department of Cell Biology, Stanford University, California 94305.
LA  - eng
GR  - AI17892/AI/NIAID NIH HHS/United States
GR  - AI24258/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Amino Acid Sequence
MH  - Epitopes/analysis
MH  - HLA Antigens/*genetics/immunology
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - Humans
MH  - *Polymorphism, Genetic
MH  - Protein Conformation
RF  - 16
EDAT- 1988/12/23 00:00
MHDA- 1988/12/23 00:01
CRDT- 1988/12/23 00:00
PHST- 1988/12/23 00:00 [pubmed]
PHST- 1988/12/23 00:01 [medline]
PHST- 1988/12/23 00:00 [entrez]
AID - 0002-9343(88)90369-5 [pii]
AID - 10.1016/0002-9343(88)90369-5 [doi]
PST - ppublish
SO  - Am J Med. 1988 Dec 23;85(6A):2-5. doi: 10.1016/0002-9343(88)90369-5.