PMID- 2462349
OWN - NLM
STAT- MEDLINE
DCOM- 19890125
LR  - 20190626
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 85
IP  - 6A
DP  - 1988 Dec 23
TI  - Major histocompatibility complex genes in systemic lupus erythematosus, Sjogren's 
      syndrome, and polymyositis.
PG  - 38-41
AB  - Current concepts about the roles of human leukocyte antigen (HLA) and complement 
      genes in predisposing to connective tissue diseases are reviewed. Precise 
      localization of disease conferring alleles and epitopes is confounded by two 
      major phenomena: (1) clinical and serologic heterogeneity of the diseases and 
      associations of several different HLA alleles with different and often 
      overlapping autoantibody responses; and (2) linkage disequilibrium of many 
      potentially relevant gene loci located on the disease-associated HLA haplotypes. 
      Using molecular genetic tools in serologically homogeneous patient populations, 
      and across racial lines, the Ro (SS-A) and la (SS-B) autoantibody responses in 
      systemic lupus erythematosus and Sjogren's syndrome appear to associate most 
      strongly with HLA-DQ alleles, whereas the anti-Jo-1 autoantibody in myositis 
      correlates best with HLA-DRw52. A gene deletion of C4A within HLA predisposes to 
      systemic lupus erythematosus in both white and black patients.
FAU - Arnett, F C
AU  - Arnett FC
AD  - Department of Internal Medicine, University of Texas Medical School, Houston 
      77225.
FAU - Goldstein, R
AU  - Goldstein R
FAU - Duvic, M
AU  - Duvic M
FAU - Reveille, J D
AU  - Reveille JD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Antibodies, Antinuclear/analysis
MH  - Epitopes/genetics
MH  - Genetic Linkage
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*genetics/immunology
MH  - *Major Histocompatibility Complex
MH  - Myositis/*genetics/immunology
MH  - Sjogren's Syndrome/*genetics/immunology
RF  - 15
EDAT- 1988/12/23 00:00
MHDA- 1988/12/23 00:01
CRDT- 1988/12/23 00:00
PHST- 1988/12/23 00:00 [pubmed]
PHST- 1988/12/23 00:01 [medline]
PHST- 1988/12/23 00:00 [entrez]
AID - 10.1016/0002-9343(88)90381-6 [doi]
PST - ppublish
SO  - Am J Med. 1988 Dec 23;85(6A):38-41. doi: 10.1016/0002-9343(88)90381-6.