PMID- 24623964
OWN - NLM
STAT- MEDLINE
DCOM- 20140930
LR  - 20221207
IS  - 1090-0535 (Electronic)
IS  - 1090-0535 (Linking)
VI  - 20
DP  - 2014
TI  - Candidate gene association study for diabetic retinopathy in Chinese patients 
      with type 2 diabetes.
PG  - 200-14
AB  - PURPOSE: To investigate whether variants in a set of eight candidate genes are 
      associated with diabetic retinopathy (DR) in a cohort of Chinese patients with 
      type 2 diabetes mellitus (T2DM). METHODS: Case-control study. Patients with T2DM 
      were recruited from the Desheng community in urban Beijing and assigned into a DR 
      group or diabetic without retinopathy (DWR) group, based on the duration of 
      diabetes and grading of fundus images. Twenty-six single-nucleotide polymorphisms 
      (SNPs) within eight candidate genes, including PPARgamma, vascular endothelial growth 
      factor (VEGF) and its receptor kinase insert domain receptor (KDR), 
      erythropoietin, aldose reductase, protein kinase C-beta, angiotensin-converting 
      enzyme, and intercellular adhesion molecule 1, were analyzed using the MassARRAY 
      genotyping system. RESULTS: A total of 500 patients with T2DM (216 with DR and 
      284 with DWR) were enrolled in the study. Significant associations of DR were 
      noted with genotypes of four SNPs-rs699947 (p<0.001), rs833061 (p = 0.001), 
      rs13207351 (p<0.001), and rs2146323 (p=0.006)--in the VEGF gene and one variant, 
      rs2071559, in the KDR gene (p=0.034). After adjustment for covariates, 
      significant association of DR remained with the homozygous genotype of the minor 
      allele for the SNPs rs699947 (odds ratio [OR] = 3.54, 95% confidence interval 
      [CI]: 1.12-11.19), rs833061 (OR = 3.72, 95% CI: 1.17-11.85), rs13207351 (OR = 
      3.76, 95% CI: 1.21-11.71), and rs2146323 (OR = 2.8, 95% CI: 1.46-5.37) in the 
      VEGF gene as well as the SNP rs2071559 (OR = 1.62, 95% CI: 1.08-2.41) in the KDR 
      gene. However, only rs699947 and rs13207351 in the VEGF gene remained 
      statistically significant after Bonferroni correction. No associations were found 
      in other genes tested. CONCLUSIONS: These data expanded previous observations on 
      the association of DR with variants in the VEGF gene in Chinese patients with 
      T2DM. Moreover, a possible association between DR and KDR polymorphisms is 
      suggested.
FAU - Yang, Xiufen
AU  - Yang X
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China ; 
      Department of Ophthalmology, the Friendship Hospital, Capital Medical University, 
      Beijing, China.
FAU - Deng, Yu
AU  - Deng Y
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China ; 
      Department of Ophthalmology, Fu Xing Hospital, Capital Medical University, 
      Beijing, China.
FAU - Gu, Hong
AU  - Gu H
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
FAU - Ren, Xuetao
AU  - Ren X
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China ; Sekwa 
      Institute of Vision Science, Beijing, China.
FAU - Li, Na
AU  - Li N
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
FAU - Lim, Apiradee
AU  - Lim A
AD  - Department of Mathematics and Computer Science, Faculty of Science and 
      Technology, Prince of Songkla University, Pattani Campus, Pattani, Thailand.
FAU - Snellingen, Torkel
AU  - Snellingen T
AD  - Sekwa Institute of Vision Science, Beijing, China.
FAU - Liu, Xipu
AU  - Liu X
AD  - Sekwa Institute of Vision Science, Beijing, China.
FAU - Wang, Ningli
AU  - Wang N
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
FAU - Liu, Ningpu
AU  - Liu N
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140303
PL  - United States
TA  - Mol Vis
JT  - Molecular vision
JID - 9605351
RN  - 0 (Biomarkers)
SB  - IM
MH  - Alleles
MH  - Asian People/*genetics
MH  - Biomarkers/metabolism
MH  - China
MH  - Diabetes Mellitus, Type 2/*complications/*genetics
MH  - Diabetic Retinopathy/*complications/*genetics
MH  - Gene Frequency/genetics
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes/genetics
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Multivariate Analysis
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Risk Factors
PMC - PMC3945804
EDAT- 2014/03/14 06:00
MHDA- 2014/10/01 06:00
PMCR- 2014/01/01
CRDT- 2014/03/14 06:00
PHST- 2013/02/23 00:00 [received]
PHST- 2014/02/28 00:00 [accepted]
PHST- 2014/03/14 06:00 [entrez]
PHST- 2014/03/14 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 19 [pii]
PST - epublish
SO  - Mol Vis. 2014 Mar 3;20:200-14. eCollection 2014.