PMID- 24624272
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140313
LR  - 20211022
IS  - 2005-6419 (Print)
IS  - 2005-7563 (Electronic)
IS  - 2005-6419 (Linking)
VI  - 66
IP  - 2
DP  - 2014 Feb
TI  - Effect of milrinone on the inflammatory response and NF-kB activation in renal 
      ischemia-reperfusion injury in mice.
PG  - 136-42
LID - 10.4097/kjae.2014.66.2.136 [doi]
AB  - BACKGROUND: Milrinone increases intracellular adenosine 3',5'-cyclic 
      monophosphate concentration and enhances vascular relaxation. Nuclear 
      factor-kappa B (NF-kB) plays a key role in inflammatory responses during 
      ischemia-reperfusion (I/R) injury. We aimed to investigate the effect of 
      milrinone on the inflammatory responses and NF-kB activation in renal I/R injury 
      in mice. METHODS: Thirty C57BL/6 mice were allocated into 3 groups. In group S (n 
      = 10), only right nephrectomy was done. In group C (n = 10), the left kidney was 
      subjected to 30 min of ischemia after right nephrectomy. In group M (n = 10), 
      milrinone (5 microg/kg) was administered before ischemia. After 24 hours of 
      reperfusion, the serum creatinine was measured, kidney samples were obtained for 
      histology, and expressions of NF-kB and proinflammatory cytokines were analyzed. 
      RESULTS: In group C, the serum creatinine concentration was markedly elevated, 
      compared with group S. Creatinine concentration in group M was also elevated, but 
      it was significantly lower than that in group C. Histologic evidence of renal 
      damage was severe in group C, but it was improved in group M. In groups C and M, 
      expression of NF-kB, tumor necrosis factor-alpha (TNF-alpha), intercellular adhesion 
      molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1) and macrophage 
      inflammatory protein-2 (MIP-2) mRNA increased significantly compared with group S 
      (P < 0.05). But group M showed a lower expression of NF-kB, TNF-alpha, ICAM-1, MCP-1 
      and MIP-2 mRNA than group C (P < 0.05). CONCLUSIONS: Milrinone treatment 
      attenuates the renal inflammatory response and activation of NF-kB, resulting in 
      improvement of renal function and tissue injury.
FAU - Jung, Hong Soo
AU  - Jung HS
AD  - Department of Anesthesiology and Pain Medicine, College of Medicine, St. 
      Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
FAU - Joo, Jin-Deok
AU  - Joo JD
AD  - Department of Anesthesiology and Pain Medicine, College of Medicine, St. 
      Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
FAU - Kim, Dae-Woo
AU  - Kim DW
AD  - Department of Anesthesiology and Pain Medicine, College of Medicine, St. 
      Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
FAU - In, Jang Hyeok
AU  - In JH
AD  - Department of Anesthesiology and Pain Medicine, College of Medicine, St. 
      Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
FAU - Roh, Misun
AU  - Roh M
AD  - Department of Anesthesiology and Pain Medicine, College of Medicine, St. 
      Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
FAU - Jeong, Jong-Tae
AU  - Jeong JT
AD  - Department of Anesthesiology and Pain Medicine, College of Medicine, St. 
      Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
FAU - Noh, Seung June
AU  - Noh SJ
AD  - The Research Institute of Medical Science, St. Vincent's Hospital, The Catholic 
      University of Korea, Suwon, Korea.
FAU - Choi, Jin Woo
AU  - Choi JW
AD  - Department of Anesthesiology and Pain Medicine, College of Medicine, St. 
      Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140228
PL  - Korea (South)
TA  - Korean J Anesthesiol
JT  - Korean journal of anesthesiology
JID - 101502451
PMC - PMC3948441
OTO - NOTNLM
OT  - Ischemia-reperfusion injury
OT  - Milrinone
OT  - Nuclear-factor-kappa B
EDAT- 2014/03/14 06:00
MHDA- 2014/03/14 06:01
PMCR- 2014/02/01
CRDT- 2014/03/14 06:00
PHST- 2013/07/16 00:00 [received]
PHST- 2013/10/15 00:00 [revised]
PHST- 2013/10/16 00:00 [accepted]
PHST- 2014/03/14 06:00 [entrez]
PHST- 2014/03/14 06:00 [pubmed]
PHST- 2014/03/14 06:01 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - 10.4097/kjae.2014.66.2.136 [doi]
PST - ppublish
SO  - Korean J Anesthesiol. 2014 Feb;66(2):136-42. doi: 10.4097/kjae.2014.66.2.136. 
      Epub 2014 Feb 28.