PMID- 24624298
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140313
LR  - 20211021
IS  - 2090-2824 (Print)
IS  - 2090-2832 (Electronic)
IS  - 2090-2824 (Linking)
VI  - 2014
DP  - 2014
TI  - Prognostic significance of circulating and endothelial progenitor cell markers in 
      type 2 diabetic foot.
PG  - 589412
LID - 10.1155/2014/589412 [doi]
LID - 589412
AB  - Objective. We studied circulating precursor cells (CPC) in type 2 diabetes 
      mellitus (T2DM) with neuropathic foot lesions with or without critical limb 
      ischemia and relationships between endothelial precursor cells (EPC) and 
      peripheral neuropathy. Methods and Subjects. We measured peripheral blood CD34, 
      CD133, and CD45 markers for CPC and KDR, CD31 markers for EPC by citofluorimetry 
      and systemic neural nociceptor CGRP (calcitonin gene related protein) by ELISA in 
      8 healthy controls (C) and 62 T2DM patients: 14 with neuropathy (N), 20 with 
      neuropathic foot lesions (N1), and 28 with neuroischemic recent revascularized 
      (N2) foot lesions. Timing of lesions was: acute (until 6 weeks), healed, and not 
      healed. Results. CD34+ and CD133+ were reduced in N, N1, and N2 versus C, and 
      CD34+ were lower in N2 versus N1 (P = 0.03). In N2 CD34+KDR+ remain elevated in 
      healed versus chronic lesions and, in N1 CD133+31+ were elevated in acute 
      lesions. CGRP was reduced in N2 and N1 versus C (P < 0.04 versus C 26 +/- 2 pg/mL). 
      CD34+KDR+ correlated in N2 with oximetry and negatively in N1 with CGRP. 
      Conclusions. CD34+ CPC are reduced in diabetes with advanced complications and 
      diabetic foot. CD34+KDR+ and CD31+133+ EPC differentiation could have a 
      prognostic and therapeutic significance in the healing process of neuropathic and 
      neuroischemic lesions.
FAU - Sambataro, Maria
AU  - Sambataro M
AD  - Metabolism Disease and Clinical Nutrition Unit, Santa Maria di Ca' Foncello 
      Hospital, Piazza Ospedale 1, 31100 Treviso, Italy.
FAU - Seganfreddo, Elena
AU  - Seganfreddo E
AD  - Metabolism Disease and Clinical Nutrition Unit, Santa Maria di Ca' Foncello 
      Hospital, Piazza Ospedale 1, 31100 Treviso, Italy.
FAU - Canal, Fabio
AU  - Canal F
AD  - Department of Pathology, Santa Maria di Ca' Foncello Hospital, Treviso, Italy.
FAU - Furlan, Anna
AU  - Furlan A
AD  - Hematology Unit, Santa Maria di Ca' Foncello Hospital, Treviso, Italy.
FAU - Del Pup, Laura
AU  - Del Pup L
AD  - Immunohematology and Transfusion Service, Santa Maria di Ca' Foncello Hospital, 
      Treviso, Italy.
FAU - Niero, Monia
AU  - Niero M
AD  - Department of Pathology, Santa Maria di Ca' Foncello Hospital, Treviso, Italy.
FAU - Paccagnella, Agostino
AU  - Paccagnella A
AD  - Metabolism Disease and Clinical Nutrition Unit, Santa Maria di Ca' Foncello 
      Hospital, Piazza Ospedale 1, 31100 Treviso, Italy.
FAU - Gherlinzoni, Filippo
AU  - Gherlinzoni F
AD  - Hematology Unit, Santa Maria di Ca' Foncello Hospital, Treviso, Italy.
FAU - Dei Tos, Angelo Paolo
AU  - Dei Tos AP
AD  - Department of Pathology, Santa Maria di Ca' Foncello Hospital, Treviso, Italy.
LA  - eng
PT  - Journal Article
DEP - 20140203
PL  - United States
TA  - Int J Vasc Med
JT  - International journal of vascular medicine
JID - 101542608
PMC - PMC3929532
EDAT- 2014/03/14 06:00
MHDA- 2014/03/14 06:01
PMCR- 2014/02/03
CRDT- 2014/03/14 06:00
PHST- 2013/06/22 00:00 [received]
PHST- 2013/11/10 00:00 [accepted]
PHST- 2014/03/14 06:00 [entrez]
PHST- 2014/03/14 06:00 [pubmed]
PHST- 2014/03/14 06:01 [medline]
PHST- 2014/02/03 00:00 [pmc-release]
AID - 10.1155/2014/589412 [doi]
PST - ppublish
SO  - Int J Vasc Med. 2014;2014:589412. doi: 10.1155/2014/589412. Epub 2014 Feb 3.