PMID- 2462575
OWN - NLM
STAT- MEDLINE
DCOM- 19890127
LR  - 20190709
IS  - 0190-9622 (Print)
IS  - 0190-9622 (Linking)
VI  - 19
IP  - 6
DP  - 1988 Dec
TI  - Differential expression of major histocompatibility complex class II antigens on 
      human keratinocytes.
PG  - 1030-7
AB  - Skin biopsies from 136 patients with 30 different dermatoses and eight biopsies 
      of normal skin were investigated with the avidin-biotin-peroxidase complex method 
      with regard to the expression of major histocompatibility complex class II 
      antigens human leukocyte antigen (HLA) HLA-DR, HLA-DQ, HLA-DP on keratinocytes. 
      In normal skin the expression of these antigens was restricted to acrosyringia 
      and Langerhans cells. In the dermatoses investigated HLA-DR was found in 51.5% 
      (70 of 136), HLA-DQ in 24.3% (33 of 136), and HLA-DP in 20.5% (8 of 39). In 37 
      cases (27.2%) only HLA-DR could be detected, whereas in 33 cases (24.3%) HLA-DR 
      was expressed jointly with HLA-DQ. Coexpression of HLA-DR and HLA-DQ was found 
      especially often in cutaneous T cell lymphomas, skin tumors, and inflammatory 
      dermatoses.
FAU - Niedecken, H
AU  - Niedecken H
AD  - Dermatology Division, University of Bonn, West Germany.
FAU - Lutz, G
AU  - Lutz G
FAU - Bauer, R
AU  - Bauer R
FAU - Kreysel, H W
AU  - Kreysel HW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 68238-35-7 (Keratins)
SB  - IM
MH  - Epidermis/*immunology
MH  - HLA-D Antigens/*analysis
MH  - HLA-DP Antigens/analysis
MH  - HLA-DQ Antigens/analysis
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Keratins
MH  - Skin Diseases/*immunology
EDAT- 1988/12/01 00:00
MHDA- 1988/12/01 00:01
CRDT- 1988/12/01 00:00
PHST- 1988/12/01 00:00 [pubmed]
PHST- 1988/12/01 00:01 [medline]
PHST- 1988/12/01 00:00 [entrez]
AID - S0190-9622(88)70268-6 [pii]
AID - 10.1016/s0190-9622(88)70268-6 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 1988 Dec;19(6):1030-7. doi: 10.1016/s0190-9622(88)70268-6.