PMID- 24625830
OWN - NLM
STAT- MEDLINE
DCOM- 20141228
LR  - 20140521
IS  - 1877-718X (Electronic)
IS  - 1877-7171 (Linking)
VI  - 4
IP  - 2
DP  - 2014
TI  - Olfactory dysfunction and dementia in Parkinson's disease.
PG  - 181-7
LID - 10.3233/JPD-130277 [doi]
AB  - Dementia is one of the most debilitating symptoms of Parkinson's disease (PD), 
      but the development of dementia is still difficult to predict at early stages of 
      the disease. We recently found that hyposmia, one of the most typical non-motor 
      features of PD, was a predictive feature of Parkinson's disease with dementia 
      (PDD). In that work, multivariate logistic analysis identified severe hyposmia 
      and visuoperceptual impairment as independent risk factors for subsequent 
      dementia within 3 years. The patients with severe hyposmia had an 18.7-fold 
      increase in their risk of dementia for each 1 SD (2.8) decrease in scores on the 
      odor stick identification test for Japanese (OSIT-J). We also found an 
      association between severe hyposmia and a specific pattern of cerebral metabolic 
      decline, which was identical to findings observed in PDD. Furthermore, volumetric 
      magnetic resonance imaging analyses demonstrated close relationships between 
      olfactory dysfunction and atrophy of focal brain structures, including the 
      amygdala and other limbic structures. Our findings suggest that brain regions 
      related to olfactory function are closely associated with cognitive decline and 
      that severe hyposmia is a prominent clinical feature that predicts the subsequent 
      development of PDD. We have now started a randomized, double-blind study using 
      donepezil for the PD group with severe hyposmia. We hope that this clinical trial 
      will allow us to establish a therapeutic intervention that can improve the 
      prognosis of advanced PD.
FAU - Takeda, Atsushi
AU  - Takeda A
AD  - Department of Neurology, National Hospital Organization, Sendai-Nishitgaga 
      Hospital, Kagitori-honcho, Taihaku-ku, Sendai, Japan.
FAU - Baba, Toru
AU  - Baba T
AD  - Department of Behavioral Neurology and Cognitive Neuroscience, Seiryo-machi, 
      Aoba-ku, Sendai, Japan.
FAU - Kikuchi, Akio
AU  - Kikuchi A
AD  - Department of Neurology, Tohoku University Graduate School of Medicine, 
      Seiryo-machi, Aoba-ku, Sendai, Japan.
FAU - Hasegawa, Takafumi
AU  - Hasegawa T
AD  - Department of Neurology, Tohoku University Graduate School of Medicine, 
      Seiryo-machi, Aoba-ku, Sendai, Japan.
FAU - Sugeno, Naoto
AU  - Sugeno N
AD  - Department of Neurology, Tohoku University Graduate School of Medicine, 
      Seiryo-machi, Aoba-ku, Sendai, Japan.
FAU - Konno, Masatoshi
AU  - Konno M
AD  - Department of Neurology, Tohoku University Graduate School of Medicine, 
      Seiryo-machi, Aoba-ku, Sendai, Japan.
FAU - Miura, Emiko
AU  - Miura E
AD  - Department of Neurology, National Hospital Organization, Sendai-Nishitgaga 
      Hospital, Kagitori-honcho, Taihaku-ku, Sendai, Japan.
FAU - Mori, Etsuro
AU  - Mori E
AD  - Department of Behavioral Neurology and Cognitive Neuroscience, Seiryo-machi, 
      Aoba-ku, Sendai, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - J Parkinsons Dis
JT  - Journal of Parkinson's disease
JID - 101567362
SB  - IM
MH  - Aged
MH  - Brain/metabolism
MH  - Dementia/*diagnosis/*etiology/metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Olfaction Disorders/*etiology/metabolism
MH  - Parkinson Disease/*complications/metabolism
MH  - Randomized Controlled Trials as Topic
MH  - Risk Factors
OTO - NOTNLM
OT  - Hyposmia
OT  - MRI
OT  - OSIT-J
OT  - PET
OT  - Parkinson's disease with dementia
EDAT- 2014/03/15 06:00
MHDA- 2014/12/30 06:00
CRDT- 2014/03/15 06:00
PHST- 2014/03/15 06:00 [entrez]
PHST- 2014/03/15 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
AID - P6L65L287556U534 [pii]
AID - 10.3233/JPD-130277 [doi]
PST - ppublish
SO  - J Parkinsons Dis. 2014;4(2):181-7. doi: 10.3233/JPD-130277.