PMID- 24625884
OWN - NLM
STAT- MEDLINE
DCOM- 20141217
LR  - 20221207
IS  - 1745-7262 (Electronic)
IS  - 1008-682X (Print)
IS  - 1008-682X (Linking)
VI  - 16
IP  - 3
DP  - 2014 May-Jun
TI  - The influence of prostate volume on cancer detection in the Chinese population.
PG  - 482-6
LID - 10.4103/1008-682X.125905 [doi]
AB  - In western populations, prostate volume (PV) has been proven to be one of the 
      strongest predictors of detecting prostate cancer (PCa) in biopsies. We performed 
      this study in a biopsy cohort, to evaluate associations among the prostate 
      volume, prostate-specific antigen (PSA) and PCa detection in the Chinese 
      population. Between the years, 2007-13, 1486 men underwent prostate biopsy at 
      Huashan Hospital, Fudan University, Shanghai, China. The study population was 
      divided into two groups for analysis according to total PSA (tPSA) range (4 ng 
      ml-1 < tPSA </= 20 ng ml-1 and tPSA > 20 ng ml-1 ). PV, age, tPSA, digital rectal 
      examination (DRE) and transrectal ultrasound (TRUS) results were also included in 
      the analysis. Although the positive biopsy rates decreased in both tPSA range 
      groups, the downtrend was more pronounced in the 4 ng ml-1 < tPSA </= 20 ng ml-1 
      group; therefore, we focused on 853 men in this group with increasing PV. In 
      multivariate logistic regression analysis, only DRE was found to be associated 
      with PCa in four PV groups (P < 0.05) and tPSA did not show a good predictive 
      ability when PV exceeded 50 ml (P > 0.05). Further, it may suggest that with 
      increasing PV, the cancer detection rate decreased in men with different tPSA, 
      DRE and TRUS nodule statuses (all P values for trends were <0.001). Our study 
      indicates that in tPSA ranging from 4 to 20 ng ml-1 , the use of PV ranges of 
      0-35 ml, 35-50 ml and > 50 ml might be taken into consideration for the biopsy 
      decision-making in the Chinese population.
FAU - Wu, Yi-Shuo
AU  - Wu YS
FAU - Na, Rong
AU  - Na R
FAU - Xu, Jian-Feng
AU  - Xu JF
FAU - Bai, Pei-De
AU  - Bai PD
FAU - Jiang, Hao-Wen
AU  - Jiang HW
AD  - Department of Urology, Huashan Hospital; Urology Research Center, Fudan 
      University, Shanghai, China, .
FAU - Ding, Qiang
AU  - Ding Q
AD  - Department of Urology, Huashan Hospital; Urology Research Center, Fudan 
      University, Shanghai, China, .
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Asian J Androl
JT  - Asian journal of andrology
JID - 100942132
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - Biopsy
MH  - China
MH  - Cohort Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Organ Size
MH  - Prostate/*pathology
MH  - Prostate-Specific Antigen/blood
MH  - Prostatic Neoplasms/blood/*diagnosis/*pathology
MH  - Risk Factors
PMC - PMC4023383
EDAT- 2014/03/15 06:00
MHDA- 2014/12/18 06:00
PMCR- 2014/05/01
CRDT- 2014/03/15 06:00
PHST- 2014/03/15 06:00 [entrez]
PHST- 2014/03/15 06:00 [pubmed]
PHST- 2014/12/18 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - 125905 [pii]
AID - AJA-16-482 [pii]
AID - 10.4103/1008-682X.125905 [doi]
PST - ppublish
SO  - Asian J Androl. 2014 May-Jun;16(3):482-6. doi: 10.4103/1008-682X.125905.