PMID- 24626170
OWN - NLM
STAT- MEDLINE
DCOM- 20140925
LR  - 20211021
IS  - 2092-6413 (Electronic)
IS  - 1226-3613 (Print)
IS  - 1226-3613 (Linking)
VI  - 46
IP  - 3
DP  - 2014 Mar 14
TI  - Mucosal dendritic cells shape mucosal immunity.
PG  - e84
LID - 10.1038/emm.2014.16 [doi]
AB  - Dendritic cells (DCs) are key modulators that shape the immune system. In mucosal 
      tissues, DCs act as surveillance systems to sense infection and also function as 
      professional antigen-presenting cells that stimulate the differentiation of naive 
      T and B cells. On the basis of their molecular expression, DCs can be divided 
      into several subsets with unique functions. In this review, we focus on 
      intestinal DC subsets and their function in bridging the innate signaling and 
      adaptive immune systems to maintain the homeostasis of the intestinal immune 
      environment. We also review the current strategies for manipulating mucosal DCs 
      for the development of efficient mucosal vaccines to protect against infectious 
      diseases.
FAU - Chang, Sun-Young
AU  - Chang SY
AD  - Laboratory of Microbiology, College of Pharmacy, Ajou University, Suwon, Korea.
FAU - Ko, Hyun-Jeong
AU  - Ko HJ
AD  - Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National 
      University, Chuncheon, Korea.
FAU - Kweon, Mi-Na
AU  - Kweon MN
AD  - Mucosal Immunology Section, International Vaccine Institute, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140314
PL  - United States
TA  - Exp Mol Med
JT  - Experimental & molecular medicine
JID - 9607880
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
MH  - Immunity, Mucosal
MH  - Intestinal Mucosa/cytology/*immunology
MH  - T-Lymphocytes, Helper-Inducer/immunology
PMC - PMC3972789
EDAT- 2014/03/15 06:00
MHDA- 2014/09/26 06:00
PMCR- 2014/03/01
CRDT- 2014/03/15 06:00
PHST- 2013/11/27 00:00 [received]
PHST- 2013/12/21 00:00 [accepted]
PHST- 2014/03/15 06:00 [entrez]
PHST- 2014/03/15 06:00 [pubmed]
PHST- 2014/09/26 06:00 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - emm201416 [pii]
AID - 10.1038/emm.2014.16 [doi]
PST - epublish
SO  - Exp Mol Med. 2014 Mar 14;46(3):e84. doi: 10.1038/emm.2014.16.