PMID- 24627246 OWN - NLM STAT- MEDLINE DCOM- 20140829 LR - 20150627 IS - 1468-2079 (Electronic) IS - 0007-1161 (Linking) VI - 98 IP - 7 DP - 2014 Jul TI - Frequency of abnormal retinal nerve fibre layer and ganglion cell layer SDOCT scans in healthy eyes and glaucoma suspects in a prospective longitudinal study. PG - 920-5 AB - BACKGROUND/AIMS: To examine the frequency of abnormal retinal nerve fibre layer thickness (RNFLT) and ganglion cell complex (GCC) measurements among healthy and glaucoma suspect and preperimetric glaucoma (GSPPG) eyes in a prospective longitudinal study. METHODS: Normal and GSPPG eyes with >/= 18 months follow-up were included. Spectral-domain optical coherence tomography (SDOCT) was performed annually in normal and biannually in GSPPG eyes. One eye was randomly selected for inclusion. RNFLT and GCC parameters with p>5% were classified as 'within normal limits (WNL)' and p<1% were classified as 'outside normal limits (ONL)'. RESUlts: 23 normal and 74 GSPPG eyes were followed for a mean 43.4 +/- 9.6 months. During serial follow-up, 100% and 91% of normal eyes had all RNFLT and GCC parameters classified as WNL, respectively. 27 (37%) and 17 (23%) of GSPPG eyes had an ONL classification in at least one RNFLT and GCC parameter, respectively. A high percentage (41%-56%) of RNFLT and GCC measurements classified as ONL were not replicated on subsequent scans. The rates of loss for all parameters were similar (p>0.05) between the groups. CONCLUSIONS: Specificity in this sample of healthy eyes was very high for RNFLT and GCC parameters. Confirmation of suspected SDOCT abnormalities is recommended to differentiate reproducible loss from long-term variability. FAU - Iverson, Shawn M AU - Iverson SM AD - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Palm Beach Garden, Florida, USA. FAU - Feuer, William J AU - Feuer WJ FAU - Shi, Wei AU - Shi W FAU - Greenfield, David S AU - Greenfield DS CN - Advanced Imaging for Glaucoma Study Group LA - eng GR - P30-EY014801/EY/NEI NIH HHS/United States GR - R01-EY013516/EY/NEI NIH HHS/United States PT - Journal Article PT - Observational Study PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PL - England TA - Br J Ophthalmol JT - The British journal of ophthalmology JID - 0421041 SB - IM MH - Adult MH - Aged MH - Female MH - Glaucoma, Open-Angle/*diagnosis/physiopathology MH - Gonioscopy MH - Healthy Volunteers MH - Humans MH - Intraocular Pressure/physiology MH - Longitudinal Studies MH - Male MH - Middle Aged MH - Nerve Fibers/*pathology MH - Ocular Hypertension/*diagnosis/physiopathology MH - Prospective Studies MH - Retinal Ganglion Cells/*pathology MH - *Tomography, Optical Coherence MH - Tonometry, Ocular MH - Visual Acuity/physiology MH - Visual Field Tests MH - Visual Fields EDAT- 2014/03/15 06:00 MHDA- 2014/08/30 06:00 CRDT- 2014/03/15 06:00 PHST- 2014/03/15 06:00 [entrez] PHST- 2014/03/15 06:00 [pubmed] PHST- 2014/08/30 06:00 [medline] AID - bjophthalmol-2013-303877 [pii] AID - 10.1136/bjophthalmol-2013-303877 [doi] PST - ppublish SO - Br J Ophthalmol. 2014 Jul;98(7):920-5. doi: 10.1136/bjophthalmol-2013-303877.