PMID- 24628093
OWN - NLM
STAT- MEDLINE
DCOM- 20150331
LR  - 20181202
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 15
IP  - 5
DP  - 2014 Jul
TI  - BDNF blood levels after electroconvulsive therapy in patients with mood 
      disorders: a systematic review and meta-analysis.
PG  - 411-8
LID - 10.3109/15622975.2014.892633 [doi]
AB  - OBJECTIVES: To evaluate whether electroconvulsive therapy (ECT), a very effective 
      non-pharmacological treatment for mood disorders, induces neurotrophic effects, 
      indexed by the measurement of peripheral brain-derived neurotrophic factor (BDNF) 
      levels. METHODS: Systematic review and meta-analysis of clinical trials published 
      in PubMed/Medline from the first date available to October 2013. We included 
      studies measuring pre- and post-BDNF blood levels under ECT in patients with mood 
      disorders in the acute depressive episode. RESULTS: Eleven studies (n = 221 
      subjects) were eligible. These studies enrolled subjects with unipolar, bipolar 
      and psychotic depression and varied regarding electrode placement (unipolar vs. 
      bipolar) and previous use of pharmacotherapy. Nonetheless, BDNF significantly 
      increased after ECT (Hedges' g pooled, random-effects model of 0.354; 95% CI = 
      0.162-0.546). The results were robust according to sensitivity analysis and 
      Begg's funnel plot did not suggest publication bias. Meta-regression results did 
      not show association of the outcome with any clinical and demographic variable, 
      including depression improvement. CONCLUSIONS: Our meta-analysis indicates that, 
      similar to pharmacological interventions, peripheral BDNF increases after ECT 
      treatment. The lack of correlation between BDNF increasing and depression 
      improvement suggests that ECT induces neurotrophic effects regardless of clinical 
      response in depression.
FAU - Brunoni, Andre R
AU  - Brunoni AR
AD  - Laboratory of Neuroscience (LIM27), Department and Institute of Psychiatry, 
      University of Sao Paulo , Sao Paulo , Brazil.
FAU - Baeken, Chris
AU  - Baeken C
FAU - Machado-Vieira, Rodrigo
AU  - Machado-Vieira R
FAU - Gattaz, Wagner F
AU  - Gattaz WF
FAU - Vanderhasselt, Marie-Anne
AU  - Vanderhasselt MA
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20140316
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - *Electroconvulsive Therapy
MH  - Humans
MH  - Mood Disorders/*blood/*therapy
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - electroconvulsive therapy
OT  - meta-analysis
OT  - mood disorders
OT  - systematic review
EDAT- 2014/03/19 06:00
MHDA- 2015/04/01 06:00
CRDT- 2014/03/18 06:00
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/04/01 06:00 [medline]
AID - 10.3109/15622975.2014.892633 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2014 Jul;15(5):411-8. doi: 10.3109/15622975.2014.892633. 
      Epub 2014 Mar 16.