PMID- 24628292 OWN - NLM STAT- MEDLINE DCOM- 20190325 LR - 20220318 IS - 1548-1336 (Electronic) IS - 0160-6972 (Linking) VI - 41 IP - 5 DP - 2015 Oct TI - A Novel Investigation of the Formation of Titanium Oxide Nanotubes on Thermally Formed Oxide of Ti-6Al-4V. PG - 523-31 LID - 10.1563/aaid-joi-D-13-00340 [doi] AB - Traditionally, titanium oxide (TiO2) nanotubes (TNTs) are anodized on Ti-6Al-4V alloy (Ti-V) surfaces with native TiO2 (amorphous TiO2); subsequent heat treatment of anodized surfaces has been observed to enhance cellular response. As-is bulk Ti-V, however, is often subjected to heat treatment, such as thermal oxidation (TO), to improve its mechanical properties. Thermal oxidation treatment of Ti-V at temperatures greater than 200 degrees C and 400 degrees C initiates the formation of anatase and rutile TiO2, respectively, which can affect TNT formation. This study aims at understanding the TNT formation mechanism on Ti-V surfaces with TO-formed TiO2 compared with that on as-is Ti-V surfaces with native oxide. Thermal oxidation-formed TiO2 can affect TNT formation and surface wettability because TO-formed TiO2 is expected to be part of the TNT structure. Surface characterization was carried out with field emission scanning electron microscopy, energy dispersive x-ray spectroscopy, water contact angle measurements, and white light interferometry. The TNTs were formed on control and 300 degrees C and 600 degrees C TO-treated Ti-V samples, and significant differences in TNT lengths and surface morphology were observed. No difference in elemental composition was found. Thermal oxidation and TO/anodization treatments produced hydrophilic surfaces, while hydrophobic behavior was observed over time (aging) for all samples. Reduced hydrophobic behavior was observed for TO/anodized samples when compared with control, control/anodized, and TO-treated samples. A method for improved surface wettability and TNT morphology is therefore discussed for possible applications in effective osseointegration of dental and orthopedic implants. FAU - Butt, Arman AU - Butt A AD - 1 Department of Bioengineering, University of Illinois at Chicago, Chicago, Ill. AD - 2 Institute of Biomaterials, Tribocorrosion and Nanomedicine (IBTN), Chicago, Ill. FAU - Hamlekhan, Azhang AU - Hamlekhan A AD - 2 Institute of Biomaterials, Tribocorrosion and Nanomedicine (IBTN), Chicago, Ill. AD - 3 Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, Mich. FAU - Patel, Sweetu AU - Patel S AD - 1 Department of Bioengineering, University of Illinois at Chicago, Chicago, Ill. AD - 2 Institute of Biomaterials, Tribocorrosion and Nanomedicine (IBTN), Chicago, Ill. FAU - Royhman, Dmitry AU - Royhman D AD - 2 Institute of Biomaterials, Tribocorrosion and Nanomedicine (IBTN), Chicago, Ill. AD - 4 Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, Ill. FAU - Sukotjo, Cortino AU - Sukotjo C AD - 2 Institute of Biomaterials, Tribocorrosion and Nanomedicine (IBTN), Chicago, Ill. AD - 4 Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, Ill. FAU - Mathew, Mathew T AU - Mathew MT AD - 2 Institute of Biomaterials, Tribocorrosion and Nanomedicine (IBTN), Chicago, Ill. AD - 5 Department of Orthopedics, Rush University Medical Center, Chicago, Ill. FAU - Shokuhfar, Tolou AU - Shokuhfar T AD - 2 Institute of Biomaterials, Tribocorrosion and Nanomedicine (IBTN), Chicago, Ill. AD - 3 Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, Mich. FAU - Takoudis, Christos AU - Takoudis C AD - 1 Department of Bioengineering, University of Illinois at Chicago, Chicago, Ill. AD - 2 Institute of Biomaterials, Tribocorrosion and Nanomedicine (IBTN), Chicago, Ill. AD - 6 Department of Chemical Engineering, University of Illinois at Chicago, Chicago, Ill. LA - eng PT - Journal Article DEP - 20140315 PL - United States TA - J Oral Implantol JT - The Journal of oral implantology JID - 7801086 RN - 0 (Oxides) RN - 15FIX9V2JP (titanium dioxide) RN - D1JT611TNE (Titanium) MH - Microscopy, Electron, Scanning MH - *Nanotubes MH - *Osseointegration MH - Oxides MH - Surface Properties MH - *Titanium OTO - NOTNLM OT - Ti-6Al-4V alloy OT - anatase-rutile OT - anodization OT - nanotubes OT - osseointegration OT - thermal oxidation EDAT- 2014/03/19 06:00 MHDA- 2019/03/26 06:00 CRDT- 2014/03/18 06:00 PHST- 2014/03/18 06:00 [entrez] PHST- 2014/03/19 06:00 [pubmed] PHST- 2019/03/26 06:00 [medline] AID - 10.1563/aaid-joi-D-13-00340 [doi] PST - ppublish SO - J Oral Implantol. 2015 Oct;41(5):523-31. doi: 10.1563/aaid-joi-D-13-00340. Epub 2014 Mar 15.