PMID- 24629161
OWN - NLM
STAT- MEDLINE
DCOM- 20141110
LR  - 20140317
IS  - 1748-1716 (Electronic)
IS  - 1748-1708 (Linking)
VI  - 210
IP  - 4
DP  - 2014 Apr
TI  - The neurovascular unit - concept review.
PG  - 790-8
LID - 10.1111/apha.12250 [doi]
AB  - The cerebral hyperaemia is one of the fundamental mechanisms for the central 
      nervous system homeostasis. Due also to this mechanism, oxygen and nutrients are 
      maintained in satisfactory levels, through vasodilation and vasoconstriction. The 
      brain hyperaemia, or coupling, is accomplished by a group of cells, closely 
      related to each other; called neurovascular unit (NVU). The neurovascular unit is 
      composed by neurones, astrocytes, endothelial cells of blood-brain barrier (BBB), 
      myocytes, pericytes and extracellular matrix components. These cells, through 
      their intimate anatomical and chemical relationship, detect the needs of neuronal 
      supply and trigger necessary responses (vasodilation or vasoconstriction) for 
      such demands. Here, we review the concepts of NVU, the coupling mechanisms and 
      research strategies.
CI  - (c) 2014 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.
FAU - Muoio, V
AU  - Muoio V
AD  - Institut fur Vegetative Physiologie, Charite- Universisitatmedizin Berlin, 
      Berlin, Germany.
FAU - Persson, P B
AU  - Persson PB
FAU - Sendeski, M M
AU  - Sendeski MM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Acta Physiol (Oxf)
JT  - Acta physiologica (Oxford, England)
JID - 101262545
SB  - IM
MH  - Astrocytes/physiology
MH  - Blood Vessels/physiology
MH  - Brain/*blood supply
MH  - Homeostasis/physiology
MH  - Humans
MH  - Signal Transduction
OTO - NOTNLM
OT  - cerebral hyperaemia
OT  - neurovascular unit
OT  - pericytes
EDAT- 2014/03/19 06:00
MHDA- 2014/11/11 06:00
CRDT- 2014/03/18 06:00
PHST- 2013/06/26 00:00 [received]
PHST- 2013/08/01 00:00 [revised]
PHST- 2013/12/31 00:00 [revised]
PHST- 2014/01/27 00:00 [accepted]
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2014/11/11 06:00 [medline]
AID - 10.1111/apha.12250 [doi]
PST - ppublish
SO  - Acta Physiol (Oxf). 2014 Apr;210(4):790-8. doi: 10.1111/apha.12250.