PMID- 24630200
OWN - NLM
STAT- MEDLINE
DCOM- 20150911
LR  - 20211021
IS  - 1532-8384 (Electronic)
IS  - 0010-440X (Print)
IS  - 0010-440X (Linking)
VI  - 55
IP  - 4
DP  - 2014 May
TI  - Frequency of reporting of adverse events in randomized controlled trials of 
      psychotherapy vs. psychopharmacotherapy.
PG  - 849-55
LID - S0010-440X(14)00006-6 [pii]
LID - 10.1016/j.comppsych.2014.01.001 [doi]
AB  - BACKGROUND: Psychopharmacology and psychotherapy are the two main therapies in 
      mental health. It is common practice to consider adverse events (AEs) of 
      medications, but it's not clear this occurs with psychotherapy. AIM: This study 
      investigates the frequency with which reports of AEs occur in clinical trials 
      using either psychopharmacology alone, psychotherapy alone, or combined 
      approaches. METHODS: Forty-five articles of randomized trials published in 
      high-impact journals were chosen from a Medline search, and separated into three 
      groups of 15 articles: pharmacotherapy alone (M), psychotherapy alone (T) and 
      combined studies that looked at the effect of both a psychotherapeutic (CT) and 
      psychopharmacologic (CM) intervention. Criteria for what defines an AE were 
      established and the papers were rated for mentions of AEs in papers as a whole 
      and by each section. RESULTS: The chi(2)-analysis of AE mentions showed significant 
      differences between the four study conditions in terms of each paper as a whole 
      (chi(2):10.1,p<0.018), and by section. Medication (M+CM) and psychotherapy papers 
      (T+CT) were then combined into two groups to compare the odds that one was more 
      likely to mention AEs than the other. Bivariate logistic regression yielded 
      statistically significant odds ratios ranging from 9.33 to 20.99, with 
      medications being far more likely to mention AEs. CONCLUSION: We believe the 
      difference in reports of AEs mirrors the attitudes researchers and providers. 
      It's critical to consider, and standardize the definition of, AEs in 
      psychotherapy, and imperative to identify and address potential AEs in 
      psychotherapy research.
CI  - Published by Elsevier Inc.
FAU - Vaughan, Barney
AU  - Vaughan B
AD  - Columbia University/New York State Psychiatric Institute, 1051 Riverside Drive, 
      Unit 66, New York, NY 10032. Electronic address: bvaughan05@gmail.com.
FAU - Goldstein, Michael H
AU  - Goldstein MH
AD  - Mount Sinai Beth Israel Medical Center, New York, NY.
FAU - Alikakos, Maria
AU  - Alikakos M
AD  - Mount Sinai Beth Israel Medical Center, New York, NY.
FAU - Cohen, Lisa J
AU  - Cohen LJ
AD  - Mount Sinai Beth Israel Medical Center, New York, NY.
FAU - Serby, Michael J
AU  - Serby MJ
AD  - Mount Sinai Beth Israel Medical Center, New York, NY.
LA  - eng
GR  - T32 DA007294/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20140123
PL  - United States
TA  - Compr Psychiatry
JT  - Comprehensive psychiatry
JID - 0372612
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Combined Modality Therapy
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - *Psychotherapy
MH  - Psychotropic Drugs/*adverse effects/therapeutic use
MH  - Randomized Controlled Trials as Topic/*statistics & numerical data
MH  - Research Design/*statistics & numerical data
MH  - Risk Assessment/statistics & numerical data
MH  - *Treatment Outcome
PMC - PMC4346151
MID - NIHMS666062
EDAT- 2014/03/19 06:00
MHDA- 2015/09/12 06:00
PMCR- 2015/03/02
CRDT- 2014/03/18 06:00
PHST- 2013/02/14 00:00 [received]
PHST- 2014/01/06 00:00 [revised]
PHST- 2014/01/13 00:00 [accepted]
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/09/12 06:00 [medline]
PHST- 2015/03/02 00:00 [pmc-release]
AID - S0010-440X(14)00006-6 [pii]
AID - 10.1016/j.comppsych.2014.01.001 [doi]
PST - ppublish
SO  - Compr Psychiatry. 2014 May;55(4):849-55. doi: 10.1016/j.comppsych.2014.01.001. 
      Epub 2014 Jan 23.