PMID- 24630733
OWN - NLM
STAT- MEDLINE
DCOM- 20150527
LR  - 20221207
IS  - 1878-1780 (Electronic)
IS  - 1262-3636 (Linking)
VI  - 40
IP  - 4
DP  - 2014 Sep
TI  - Strong correlation between glycaemic variability and total glucose exposure in 
      type 2 diabetes is limited to subjects with satisfactory glycaemic control.
PG  - 272-7
LID - S1262-3636(14)00033-0 [pii]
LID - 10.1016/j.diabet.2014.01.006 [doi]
AB  - AIMS: This study investigated the relationship between markers of overall glucose 
      exposure, postprandial glucose excursions and glycaemic variability in patients 
      with type 2 diabetes mellitus (T2DM). METHODS: A total of 63 patients with T2DM 
      (mean age 56 years) were enrolled. All wore a continuous glucose monitoring 
      system (CGMS) device for 72 h to collect data on markers of overall glucose 
      exposure, postprandial glucose excursions and glycaemic variability parameters. 
      RESULTS: Spearman's correlation analysis revealed significant correlations 
      between all markers of overall glucose exposure and various parameters related to 
      glucose excursions. The percent coefficient of variation (CV) showed the 
      strongest correlation with glycated albumin (r=0.470, P<0.01). In participants 
      with HbA1c levels < 7.5% (n=33), almost all glycaemic markers and glycaemic 
      variability parameters were significantly correlated with each other. Also, all 
      postprandial glucose excursion parameters showed significant correlation with 
      other glycaemic markers, and all markers of overall glucose exposure were 
      significantly related to mean glucose, postprandial glucose excursions and 
      glycaemic variability parameters (except CV). In contrast, in participants with 
      HbA1c levels >/= 7.5% (n=30), no parameters of postprandial glucose excursions and 
      glycaemic variability were related to any markers of chronic glycaemia. 
      CONCLUSION: Postprandial glucose excursions may explain glycaemic variability and 
      total glucose exposures in well-controlled T2DM patients.
CI  - Copyright (c) 2014 Elsevier Masson SAS. All rights reserved.
FAU - Suh, S
AU  - Suh S
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Dong-A 
      University Medical Center, Dong-A University College of Medicine, Busan, Republic 
      of Korea.
FAU - Joung, J Y
AU  - Joung JY
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 
      135-710 Seoul, Republic of Korea.
FAU - Jin, S M
AU  - Jin SM
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 
      135-710 Seoul, Republic of Korea.
FAU - Kim, M Y
AU  - Kim MY
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 
      135-710 Seoul, Republic of Korea.
FAU - Bae, J C
AU  - Bae JC
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 
      135-710 Seoul, Republic of Korea.
FAU - Park, H D
AU  - Park HD
AD  - Department of Laboratory Medicine and Genetics, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Lee, M S
AU  - Lee MS
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 
      135-710 Seoul, Republic of Korea.
FAU - Lee, M K
AU  - Lee MK
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 
      135-710 Seoul, Republic of Korea.
FAU - Kim, J H
AU  - Kim JH
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 
      135-710 Seoul, Republic of Korea. Electronic address: jaehyeon@skku.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140311
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Serum Albumin)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Glycated Serum Albumin)
SB  - IM
CIN - Diabetes Metab. 2014 Sep;40(4):237-40. PMID: 24852510
MH  - Aged
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/blood/drug therapy/*metabolism
MH  - Dietary Carbohydrates/administration & dosage
MH  - Female
MH  - Glucose/*administration & dosage
MH  - Glycated Hemoglobin/metabolism
MH  - Glycation End Products, Advanced
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Postprandial Period/physiology
MH  - Serum Albumin/metabolism
MH  - Glycated Serum Albumin
OTO - NOTNLM
OT  - 1,5-Anhydroglucitol
OT  - Continuous glucose monitoring systems
OT  - Fructosamine
OT  - Glycated albumin
OT  - HbA(1c)
EDAT- 2014/03/19 06:00
MHDA- 2015/05/28 06:00
CRDT- 2014/03/18 06:00
PHST- 2013/12/03 00:00 [received]
PHST- 2014/01/24 00:00 [revised]
PHST- 2014/01/30 00:00 [accepted]
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/05/28 06:00 [medline]
AID - S1262-3636(14)00033-0 [pii]
AID - 10.1016/j.diabet.2014.01.006 [doi]
PST - ppublish
SO  - Diabetes Metab. 2014 Sep;40(4):272-7. doi: 10.1016/j.diabet.2014.01.006. Epub 
      2014 Mar 11.