PMID- 24631206
OWN - NLM
STAT- MEDLINE
DCOM- 20141218
LR  - 20200106
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 35
DP  - 2014 Jun
TI  - Effects of prenatal chronic mild stress exposure on hippocampal cell 
      proliferation, expression of GSK-3alpha, beta and NR2B in adult offspring during fear 
      extinction in rats.
PG  - 16-24
LID - S0736-5748(14)00034-3 [pii]
LID - 10.1016/j.ijdevneu.2014.02.004 [doi]
AB  - Stress during pregnancy has been implicated as a risk factor for the development 
      of many mental disorders; however, the influence of prenatal stress on the fear 
      or anxiety-related behaviors, especially the fear extinction in adult offspring 
      has been little investigated. In order to investigate how prenatal stress affects 
      fear extinction, which is regarded as a form of new learning that counteracts the 
      expression of Pavlovian's conditioned fear, a rat model of prenatal chronic mild 
      stress (PNS) was used to evaluate the effects of PNS on fear extinction in adult 
      offspring. The expression of hippocampal glycogen synthase kinase-3s (GSK-3alpha, beta), 
      N-methyl-d-aspartic acid receptors (NMDARs)-2B and the hippocampal cell 
      proliferation in dentate gyrus in the adult offspring during fear extinction were 
      studied. Our results showed that PNS significantly reduced body weight of pups, 
      indicating PNS might induce growth retardation in offspring. Moreover, PNS 
      significantly enhanced the freezing behavior of offspring at the phase of 
      extinction, suggesting PNS impaired the abilities of fear extinction learning. In 
      addition, PNS significantly increased the levels of GSK-3alpha, beta and NR2B, but 
      reduced hippocampal cell proliferation during fear extinction. Taken together, 
      our findings suggest that maternal stress during pregnancy can impair the fear 
      extinction of adult offspring, probably by affecting the neural plasticity of 
      brain.
CI  - Copyright (c) 2014 ISDN. Published by Elsevier Ltd. All rights reserved.
FAU - Li, Min
AU  - Li M
AD  - Department of Psychiatry, the First Hospital of China Medical University, 
      Shenyang 110001, China.
FAU - Li, Xiaobai
AU  - Li X
AD  - Department of Psychiatry, the First Hospital of China Medical University, 
      Shenyang 110001, China. Electronic address: xbli@mail.cmu.edu.cn.
FAU - Zhang, Xinxin
AU  - Zhang X
AD  - Department of Psychiatry, the First Hospital of China Medical University, 
      Shenyang 110001, China.
FAU - Ren, Jintao
AU  - Ren J
AD  - Department of Psychiatry, the First Hospital of China Medical University, 
      Shenyang 110001, China.
FAU - Jiang, Han
AU  - Jiang H
AD  - Department of Psychiatry, the First Hospital of China Medical University, 
      Shenyang 110001, China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Psychiatry, the First Hospital of China Medical University, 
      Shenyang 110001, China.
FAU - Ma, Yuchao
AU  - Ma Y
AD  - Department of Psychiatry, the First Hospital of China Medical University, 
      Shenyang 110001, China.
FAU - Cheng, Wenwen
AU  - Cheng W
AD  - Department of Psychiatry, the First Hospital of China Medical University, 
      Shenyang 110001, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140311
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
RN  - EC 2.7.11.1 (Gsk3b protein, rat)
RN  - EC 2.7.11.26 (Glycogen Synthase Kinase 3)
RN  - EC 2.7.11.26 (glycogen synthase kinase 3 alpha)
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - *Extinction, Psychological
MH  - *Fear
MH  - Female
MH  - Glycogen Synthase Kinase 3/*metabolism
MH  - Glycogen Synthase Kinase 3 beta
MH  - Hippocampus/embryology/*metabolism/pathology
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*metabolism/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Stress, Psychological/*metabolism/pathology
OTO - NOTNLM
OT  - Cell proliferation
OT  - Fear extinction
OT  - GSK-3alpha
OT  - GSK-3beta
OT  - NR2B
OT  - Prenatal chronic mild stress
EDAT- 2014/03/19 06:00
MHDA- 2014/12/19 06:00
CRDT- 2014/03/18 06:00
PHST- 2013/11/18 00:00 [received]
PHST- 2014/02/23 00:00 [revised]
PHST- 2014/02/23 00:00 [accepted]
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2014/12/19 06:00 [medline]
AID - S0736-5748(14)00034-3 [pii]
AID - 10.1016/j.ijdevneu.2014.02.004 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2014 Jun;35:16-24. doi: 10.1016/j.ijdevneu.2014.02.004. Epub 
      2014 Mar 11.