PMID- 24631282
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20140414
IS  - 1532-3102 (Electronic)
IS  - 0143-4004 (Linking)
VI  - 35
IP  - 5
DP  - 2014 May
TI  - Intercellular adhesion molecule-1 expression in massive chronic intervillositis: 
      implications for the invasion of maternal cells into fetal tissues.
PG  - 311-7
LID - S0143-4004(14)00080-0 [pii]
LID - 10.1016/j.placenta.2014.02.006 [doi]
AB  - INTRODUCTION: Massive chronic intervillositis (MCI), also known as chronic 
      intervillositis of unknown etiology, is a placental lesion associated with 
      massive infiltration of mononuclear cells in the intervillous space, poor 
      perinatal outcome, and high rate of recurrence. Our previous demonstration of 
      increased syncytiotrophoblast (st) intercellular adhesion molecule-1 (ICAM-1) 
      expression in villitis lesions and the finding of extensive monocyte/macrophagic 
      cells in the maternal intervillous space in MCI, led us to further investigate 
      stICAM-1 in MCI. MATERIALS AND METHODS: A cross-sectional study of placentas from 
      the third trimester of pregnancy (34-41 weeks gestation) was conducted to 
      determine stICAM-1 in MCI (n = 7). MCI stICAM-1 expression was compared to 
      stICAM-1 in villitis (n = 7) and in normal villi from placentas with (n = 7) and 
      without (n = 7) villitis. Maternal cells within villi in MCI were identified in 
      placentas mismatched for maternal/fetal human leukocyte antigen (HLA)-DRw52. 
      Villitis was diagnosed with hematoxylin and eosin staining and antibody to CD3 in 
      serial sections, and ICAM-1 in syncytiotrophoblasts was confirmed with antibodies 
      to ICAM-1 and cytokeratin. RESULTS: Placentas with MCI had higher stICAM-1 
      (79.8%) than placentas with villitis (27.1%), normal villi from placentas with 
      villitis (11.5%), and normal villi from placentas without villitis (0.3%). 
      Maternal cells were identified within villi of placentas (n = 5) mismatched 
      (mothers positive, fetuses negative) for HLA-DRw52. CONCLUSIONS: Placentas with 
      MCI have more stICAM-1 than placentas with or without villitis lacking MCI. The 
      finding that MCI and villitis have prominent stICAM-1 and maternal cells in the 
      villi suggests that MCI and villitis could have a similar pathophysiologic 
      mechanism.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Labarrere, C A
AU  - Labarrere CA
AD  - CBL Partners for Life, Indianapolis, IN, United States; Indiana University School 
      of Medicine, Indianapolis, IN, United States; Indiana University Health Methodist 
      Research Institute, Indianapolis, IN, United States. Electronic address: 
      clabarrere@sbcglobal.net.
FAU - Bammerlin, E
AU  - Bammerlin E
AD  - Indiana University Health Methodist Research Institute, Indianapolis, IN, United 
      States.
FAU - Hardin, J W
AU  - Hardin JW
AD  - Epidemiology and Biostatistics, Columbia, SC, United States.
FAU - Dicarlo, H L
AU  - Dicarlo HL
AD  - Indiana University Health Methodist Research Institute, Indianapolis, IN, United 
      States; Westside Regional Medical Center, Fort Lauderdale, FL, United States.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140228
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Adult
MH  - Chorionic Villi/*metabolism
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fetus/*metabolism/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Intercellular Adhesion Molecule-1/*metabolism
MH  - Placenta/*metabolism/pathology
MH  - Placenta Diseases/*metabolism/pathology
MH  - Pregnancy
MH  - Young Adult
OTO - NOTNLM
OT  - Chorionic villi
OT  - ICAM-1
OT  - Massive chronic intervillositis
OT  - Placenta
OT  - Syncytiotrophoblast
OT  - Villitis
EDAT- 2014/03/19 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/03/18 06:00
PHST- 2013/12/23 00:00 [received]
PHST- 2014/02/10 00:00 [revised]
PHST- 2014/02/19 00:00 [accepted]
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0143-4004(14)00080-0 [pii]
AID - 10.1016/j.placenta.2014.02.006 [doi]
PST - ppublish
SO  - Placenta. 2014 May;35(5):311-7. doi: 10.1016/j.placenta.2014.02.006. Epub 2014 
      Feb 28.