PMID- 24631466
OWN - NLM
STAT- MEDLINE
DCOM- 20150923
LR  - 20181202
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 64
IP  - 4
DP  - 2014 Oct
TI  - Homocysteine and metabolic syndrome: from clustering to additional utility in 
      prediction of coronary heart disease.
PG  - 290-6
LID - S0914-5087(14)00047-1 [pii]
LID - 10.1016/j.jjcc.2014.02.001 [doi]
AB  - BACKGROUND: The association between homocysteine (Hcy) and metabolic syndrome 
      (MetS)-related disorders remains to be unveiled. First, the role of Hcy-MetS 
      interaction in prediction of coronary heart disease (CHD) was assessed. Next, we 
      investigated whether serum Hcy improves CHD risk-prediction beyond MetS and 
      traditional risk factors (TRFs). DESIGN: A prospective study of 5893 
      community-dwelling participants (two sub-cohorts, 3286 diabetic and 2607 
      non-diabetic;  approximately  8.5 years of follow-up). METHODS: Clustering of Hcy with MetS 
      components was assessed using exploratory factor-analysis. Cox regression hazard 
      ratio (HR) was used to predict CHD using Hcy level and MetS status. Baseline 
      model included MetS and TRFs. Addition of Hcy and hyper-homocysteinemia (HHcy) to 
      the baseline model was evaluated in two separate models. RESULTS: Hcy was 
      correlated with MetS components, especially with systolic blood pressure. The 
      factor linking MetS to CHD is the factor through which Hcy is linked to MetS. 
      HHcy and MetS interacted as risk factors for CHD. CONCLUSION: Hcy adds to the 
      value of MetS and TRFs for CHD risk-prediction by reclassifying around 47.3-49.0% 
      of the overall and 21.6-28.1% of the intermediate-risk population.
CI  - Copyright (c) 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Esteghamati, Alireza
AU  - Esteghamati A
AD  - Endocrinology and Metabolism Research Center, Tehran University of Medical 
      Sciences, Tehran, Iran. Electronic address: esteghamati@tums.ac.ir.
FAU - Hafezi-Nejad, Nima
AU  - Hafezi-Nejad N
AD  - Endocrinology and Metabolism Research Center, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Zandieh, Ali
AU  - Zandieh A
AD  - Endocrinology and Metabolism Research Center, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Sheikhbahaei, Sara
AU  - Sheikhbahaei S
AD  - Endocrinology and Metabolism Research Center, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Ebadi, Maryam
AU  - Ebadi M
AD  - Endocrinology and Metabolism Research Center, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Nakhjavani, Manouchehr
AU  - Nakhjavani M
AD  - Endocrinology and Metabolism Research Center, Tehran University of Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20140314
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
CIN - J Cardiol. 2015 May;65(5):440. PMID: 25553867
CIN - J Cardiol. 2015 May;65(5):439. PMID: 25553868
MH  - Adult
MH  - Biomarkers/blood
MH  - Coronary Disease/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Homocysteine/*blood
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*blood
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Assessment
OTO - NOTNLM
OT  - Biomarkers
OT  - Clinical utility
OT  - Coronary heart disease
OT  - Homocysteine
OT  - Metabolic syndrome
EDAT- 2014/03/19 06:00
MHDA- 2015/09/24 06:00
CRDT- 2014/03/18 06:00
PHST- 2013/10/04 00:00 [received]
PHST- 2014/01/08 00:00 [revised]
PHST- 2014/02/03 00:00 [accepted]
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/09/24 06:00 [medline]
AID - S0914-5087(14)00047-1 [pii]
AID - 10.1016/j.jjcc.2014.02.001 [doi]
PST - ppublish
SO  - J Cardiol. 2014 Oct;64(4):290-6. doi: 10.1016/j.jjcc.2014.02.001. Epub 2014 Mar 
      14.