PMID- 2463176
OWN - NLM
STAT- MEDLINE
DCOM- 19890221
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 156
IP  - 1
DP  - 1988 Oct 26
TI  - Direct central effects of acute methylenedioxymethamphetamine on serotonergic 
      neurons.
PG  - 121-31
AB  - Acute peripheral administration of either the (+) or (-) stereoisomer of 
      methylenedioxymethamphetamine (MDMA) to rats results in a rapid loss of 
      tryptophan hydroxylase (TPH) activity in several brain regions. This decline in 
      enzyme activity precedes a decrease in serotonin (5-HT) concentrations in the 
      same areas. An initial rise in the concentration of 5-hydroxyindole acetic acid 
      after drug administration suggests that an increase in the turnover of 5-HT is an 
      early event in the development of these changes. Unsuccessful attempts to 
      reproduce the in vivo effects of MDMA on TPH activity using in vitro preparations 
      such as cortical slices or the mouse mastocytoma cell line, P-815, suggested a 
      requirement for an intact neuronal system or metabolism of the drug. Injection of 
      MDMA directly into several brain regions also had no effect on TPH activity or 
      5-HT concentrations. However, when brain concentrations of MDMA were maintained 
      using a constant i.c.v. infusion, TPH activity declined as observed following 
      peripheral administration. The results, therefore, indicate that the acute effect 
      of MDMA on 5-HT synthesis is a direct central effect of the drug which may be 
      triggered by a sustained increase in transmitter turnover.
FAU - Schmidt, C J
AU  - Schmidt CJ
AD  - Merrell Dow Research Institute, Cincinnati, OH 45215.
FAU - Taylor, V L
AU  - Taylor VL
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amphetamines)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - EC 1.14.16.4 (Tryptophan Hydroxylase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/administration & dosage/analogs & 
      derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Brain/drug effects/enzymology
MH  - Cerebral Cortex/drug effects
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - In Vitro Techniques
MH  - Infusions, Parenteral
MH  - Injections
MH  - Male
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Neurons/*drug effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/*metabolism
MH  - Stereoisomerism
MH  - Tryptophan Hydroxylase/*metabolism
MH  - Tumor Cells, Cultured/drug effects
EDAT- 1988/10/26 00:00
MHDA- 1988/10/26 00:01
CRDT- 1988/10/26 00:00
PHST- 1988/10/26 00:00 [pubmed]
PHST- 1988/10/26 00:01 [medline]
PHST- 1988/10/26 00:00 [entrez]
AID - 0014-2999(88)90154-9 [pii]
AID - 10.1016/0014-2999(88)90154-9 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1988 Oct 26;156(1):121-31. doi: 10.1016/0014-2999(88)90154-9.