PMID- 24632017
OWN - NLM
STAT- MEDLINE
DCOM- 20141215
LR  - 20140414
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 153
IP  - 2
DP  - 2014 Apr 28
TI  - Ethanol extracts from Hemerocallis citrina attenuate the upregulation of 
      proinflammatory cytokines and indoleamine 2,3-dioxygenase in rats.
PG  - 484-90
LID - S0378-8741(14)00178-0 [pii]
LID - 10.1016/j.jep.2014.03.001 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Hemerocallis citrina, a traditional herbal 
      medicine, has been used for the improvement of behavioral and emotional status in 
      Eastern-Asia countries. Previous studies in our laboratory demonstrated that 
      ethanol extracts from Hemerocallis citrina (HCE) enhanced monoamines and 
      brain-derived neurotrophic factor (BDNF) in depression-like model of rodents. 
      MATERIALS AND METHODS: The present study extends earlier works on the role of 
      anti-inflammation in regulating the antidepressant-like actions of HCE in rats 
      exposed to chronic unpredictable mild stress (CUMS). Frontal cortex and 
      hippocampal proinflammatory cytokines levels and indoleamine 2,3-dioxygenase 
      (IDO) activity were measured after 4-week HCE treatment in the CUMS an control 
      rats. RESULTS: Chronic administration of HCE reversed the decreased sucrose 
      preference in sucrose preference test. In addition, we also found that HCE 
      inhibited interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis 
      factor-alpha (TNF-alpha) expression, as well as IDO activity in frontal cortex and 
      hippocampus, which were increased in rats exposed to CUMS. CONCLUSIONS: Combining 
      with our previous studies, our present finding suggests that the 
      anti-inflammatory property of HCE might play a crucial role in its 
      antidepressant-like effect through, at least in part, the restoration or 
      improvement of monoaminergic and neurotrophin systems.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Liu, Xiao-Long
AU  - Liu XL
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021 Fujian province, PR China.
FAU - Luo, Liu
AU  - Luo L
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021 Fujian province, PR China.
FAU - Liu, Bin-Bin
AU  - Liu BB
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021 Fujian province, PR China.
FAU - Li, Jing
AU  - Li J
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021 Fujian province, PR China.
FAU - Geng, Di
AU  - Geng D
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021 Fujian province, PR China.
FAU - Liu, Qing
AU  - Liu Q
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021 Fujian province, PR China. 
      Electronic address: liuq@hqu.edu.cn.
FAU - Yi, Li-Tao
AU  - Yi LT
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021 Fujian province, PR China. 
      Electronic address: litao.yi@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140312
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Cytokines)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Plant Extracts)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Cytokines/antagonists & inhibitors/biosynthesis
MH  - *Ethanol/isolation & purification
MH  - Flowers
MH  - *Hemerocallis
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/*antagonists & inhibitors/biosynthesis
MH  - Inflammation Mediators/*antagonists & inhibitors/metabolism
MH  - Male
MH  - Plant Extracts/isolation & purification/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Up-Regulation/*drug effects/physiology
OTO - NOTNLM
OT  - 3-Dioxygenase.
OT  - Chronic unpredictable mild stress
OT  - Depression
OT  - Hemerocallis citrina
OT  - Indoleamine 2
OT  - Proinflammatory cytokines
EDAT- 2014/03/19 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/03/18 06:00
PHST- 2013/09/19 00:00 [received]
PHST- 2014/01/29 00:00 [revised]
PHST- 2014/03/01 00:00 [accepted]
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - S0378-8741(14)00178-0 [pii]
AID - 10.1016/j.jep.2014.03.001 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2014 Apr 28;153(2):484-90. doi: 10.1016/j.jep.2014.03.001. Epub 
      2014 Mar 12.