PMID- 24632082
OWN - NLM
STAT- MEDLINE
DCOM- 20141105
LR  - 20211021
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Print)
IS  - 0952-7915 (Linking)
VI  - 28
DP  - 2014 Jun
TI  - Regulatory constraints in the generation and differentiation of IgE-expressing B 
      cells.
PG  - 64-70
LID - S0952-7915(14)00026-0 [pii]
LID - 10.1016/j.coi.2014.02.001 [doi]
AB  - B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet 
      are heavily implicated in the pathogenesis of allergies and asthma. This review 
      discusses recent methodological advances that permit sensitive probing of 
      IgE-expressing (IgE(+)) B cells in vivo and have accordingly clarified the basic 
      behavior and fate of IgE(+) B cells during immune responses in mouse models. IgE 
      antibody secreting plasma cells can arise from extrafollicular foci, germinal 
      centers, and memory B cells. However, compared to B cells expressing other 
      isotypes, IgE(+) B cells are susceptible to multiple additional regulatory 
      constraints that restrict the size of the IgE(+) B cell pool at each stage, 
      coordinately limiting the overall magnitude, affinity, and duration of the IgE 
      antibody response.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Yang, Zhiyong
AU  - Yang Z
AD  - Cardiovascular Research Institute and Sandler Asthma Basic Research Center, 
      University of California, San Francisco, San Francisco, CA 94143, USA.
FAU - Robinson, Marcus J
AU  - Robinson MJ
AD  - Cardiovascular Research Institute and Sandler Asthma Basic Research Center, 
      University of California, San Francisco, San Francisco, CA 94143, USA.
FAU - Allen, Christopher D C
AU  - Allen CD
AD  - Cardiovascular Research Institute and Sandler Asthma Basic Research Center, 
      University of California, San Francisco, San Francisco, CA 94143, USA; Department 
      of Anatomy and Department of Microbiology & Immunology, University of California, 
      San Francisco, San Francisco, CA 94143, USA. Electronic address: 
      Chris.Allen@ucsf.edu.
LA  - eng
GR  - DP2 HL117752/HL/NHLBI NIH HHS/United States
GR  - R01 AI103146/AI/NIAID NIH HHS/United States
GR  - R01AI103146/AI/NIAID NIH HHS/United States
GR  - DP2HL117752/DP/NCCDPHP CDC HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140312
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/cytology/*immunology
MH  - *Cell Differentiation
MH  - Cell Lineage
MH  - Germinal Center/immunology
MH  - Humans
MH  - Immunoglobulin Class Switching
MH  - Immunoglobulin E/*immunology
PMC - PMC4069329
MID - NIHMS576090
EDAT- 2014/03/19 06:00
MHDA- 2014/11/06 06:00
PMCR- 2015/06/01
CRDT- 2014/03/18 06:00
PHST- 2013/12/23 00:00 [received]
PHST- 2014/02/01 00:00 [revised]
PHST- 2014/02/03 00:00 [accepted]
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2014/11/06 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - S0952-7915(14)00026-0 [pii]
AID - 10.1016/j.coi.2014.02.001 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2014 Jun;28:64-70. doi: 10.1016/j.coi.2014.02.001. Epub 2014 
      Mar 12.