PMID- 24632791
OWN - NLM
STAT- MEDLINE
DCOM- 20150821
LR  - 20190819
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 78
IP  - 5
DP  - 2014
TI  - Myocardial repolarization dispersion and late gadolinium enhancement in patients 
      with hypertrophic cardiomyopathy.
PG  - 1216-23
AB  - BACKGROUND: Growing evidence suggests that late gadolinium enhancement (LGE) at 
      cardiac magnetic resonance (CMR) is an additive marker of disease severity, and 
      possibly of arrhythmic risk, in hypertrophic cardiomyopathy (HCM). We 
      investigated the possible relationship between LGE and markers of myocardial 
      repolarization dispersion in HCM. METHODS AND RESULTS: Eighty-five HCM 
      outpatients underwent CMR and short-period electrocardiogram analysis to 
      calculate the temporal myocardial repolarization dispersion through the QT 
      variance normalized for QT mean (QTVN) and the QT variability index (QTVI). The 
      QT dispersion in the spatial domain was also obtained. Patients with LGE (62%) 
      had higher left atrial volume, maximum wall thickness, and left ventricular mass 
      (P<0.0001), as well as a greater prevalence of non-sustained ventricular 
      tachycardia (P<0.0001) and hypotensive blood pressure response (P=0.044). Both 
      QTVN and QTVI were higher in the group with LGE (P<0.0001). At multivariate 
      analysis, using QTVI as the dependent variable, %LGE (P<0.0001), age (P<0.0001), 
      left ventricular outflow obstruction (P=0.038), and sudden cardiac death risk 
      factor burden (P=0.020) reached statistical significance. Otherwise, only %LGE 
      (P=0.005) and left ventricular mass index (P=0.015) remained associated with 
      QTVN. CONCLUSIONS: Temporal myocardial repolarization dispersion correlates with 
      LGE extent. Whether these variables could be useful in HCM clinical management 
      warrants confirmation by larger prospective studies.
FAU - Magri, Damiano
AU  - Magri D
AD  - Department of Clinical and Molecular Medicine, Sapienza University.
FAU - De Cecco, Carlo Nicola
AU  - De Cecco CN
FAU - Piccirillo, Gianfranco
AU  - Piccirillo G
FAU - Mastromarino, Vittoria
AU  - Mastromarino V
FAU - Serdoz, Andrea
AU  - Serdoz A
FAU - Muscogiuri, Giuseppe
AU  - Muscogiuri G
FAU - Ricotta, Agnese
AU  - Ricotta A
FAU - Gregori, Mario
AU  - Gregori M
FAU - Marino, Laura
AU  - Marino L
FAU - Cauti, Filippo Maria
AU  - Cauti FM
FAU - Pagannone, Erika
AU  - Pagannone E
FAU - Musumeci, Maria Beatrice
AU  - Musumeci MB
FAU - Maruotti, Antonello
AU  - Maruotti A
FAU - Autore, Camillo
AU  - Autore C
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140317
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/*physiopathology
MH  - *Electrocardiography
MH  - Female
MH  - Gadolinium/*administration & dosage
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - *Myocardium
MH  - Radiography
MH  - Tachycardia, Ventricular/diagnostic imaging/physiopathology
EDAT- 2014/03/19 06:00
MHDA- 2015/08/22 06:00
CRDT- 2014/03/18 06:00
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/08/22 06:00 [medline]
AID - DN/JST.JSTAGE/circj/CJ-13-1423 [pii]
AID - 10.1253/circj.cj-13-1423 [doi]
PST - ppublish
SO  - Circ J. 2014;78(5):1216-23. doi: 10.1253/circj.cj-13-1423. Epub 2014 Mar 17.