PMID- 24633026
OWN - NLM
STAT- MEDLINE
DCOM- 20150519
LR  - 20220310
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 53
IP  - 6
DP  - 2014
TI  - Eradication of H. pylori infection in patients allergic to penicillin using 
      triple therapy with a PPI, metronidazole and sitafloxacin.
PG  - 571-5
AB  - Eradication of H. pylori in patients allergic to penicillin should be performed 
      using regimens without penicillin derivatives. We treated a total of 28 patients 
      allergic to penicillin with a proton pump inhibitor (PPI), metronidazole (250 mg 
      bid) and sitafloxacin (100 mg bid) for one to two weeks. At four to eight weeks 
      after the treatment, the patients underwent the [(13)C]-urea breath test. The 
      overall eradication rate was 100.0%. Mild adverse events were observed. Triple 
      therapy with a PPI, metronidazole and sitafloxacin is well tolerated and 
      effective for the eradication of H. pylori in patients allergic to penicillin.
FAU - Furuta, Takahisa
AU  - Furuta T
AD  - Center for Clinical Research, Hamamatsu University School of Medicine, Japan.
FAU - Sugimoto, Mitsushige
AU  - Sugimoto M
FAU - Yamade, Mihoko
AU  - Yamade M
FAU - Uotani, Takahiro
AU  - Uotani T
FAU - Sahara, Shu
AU  - Sahara S
FAU - Ichikawa, Hitomi
AU  - Ichikawa H
FAU - Kagami, Takuma
AU  - Kagami T
FAU - Yamada, Takanori
AU  - Yamada T
FAU - Osawa, Satoshi
AU  - Osawa S
FAU - Sugimoto, Ken
AU  - Sugimoto K
FAU - Watanabe, Hiroshi
AU  - Watanabe H
FAU - Umemura, Kazuo
AU  - Umemura K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Fluoroquinolones)
RN  - 0 (Penicillins)
RN  - 0 (Proton Pump Inhibitors)
RN  - 140QMO216E (Metronidazole)
RN  - 9TD681796G (sitafloxacin)
RN  - EC 1.14.14.1 (CYP2C19 protein, human)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2C19)
SB  - IM
MH  - Anti-Bacterial Agents/*administration & dosage
MH  - Breath Tests
MH  - Cytochrome P-450 CYP2C19/metabolism
MH  - Drug Administration Schedule
MH  - Drug Hypersensitivity
MH  - Drug Therapy, Combination
MH  - Female
MH  - Fluoroquinolones/*administration & dosage
MH  - Genotype
MH  - Helicobacter Infections/*drug therapy/epidemiology/prevention & control
MH  - Helicobacter pylori/*drug effects
MH  - Humans
MH  - Japan/epidemiology
MH  - Metronidazole/*administration & dosage
MH  - Middle Aged
MH  - Penicillins/immunology
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2014/03/19 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/03/18 06:00
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
AID - DN/JST.JSTAGE/internalmedicine/53.1677 [pii]
AID - 10.2169/internalmedicine.53.1677 [doi]
PST - ppublish
SO  - Intern Med. 2014;53(6):571-5. doi: 10.2169/internalmedicine.53.1677.