PMID- 24633447
OWN - NLM
STAT- MEDLINE
DCOM- 20150828
LR  - 20211021
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 231
IP  - 19
DP  - 2014 Oct
TI  - MDMA effects consistent across laboratories.
PG  - 3899-905
LID - 10.1007/s00213-014-3528-z [doi]
AB  - RATIONALE: Several laboratories have conducted placebo-controlled drug challenge 
      studies with 3,4-methylenedioxymethamphetamine (MDMA), providing a unique source 
      of data to examine the reliability of the acute effects of the drug across 
      subject samples and settings. We examined the subjective and physiological 
      responses to the drug across three different laboratories and investigated the 
      influence of prior MDMA use. METHODS: Overall, 220 healthy volunteers with 
      varying levels of previous MDMA experience participated in laboratory-based 
      studies in which they received placebo or MDMA orally (1.5 mg/kg or 125-mg fixed 
      dose) under double-blind conditions. Cardiovascular and subjective effects were 
      assessed before and repeatedly after drug administration. The studies were 
      conducted independently by investigators in Basel, San Francisco, and Chicago. 
      RESULTS: Despite methodological differences between the studies and differences 
      in the subjects' drug use histories, MDMA produced very similar cardiovascular 
      and subjective effects across the sites. The participants' prior use of MDMA was 
      inversely related to feeling "Any Drug Effect" only at sites testing more 
      experienced users. CONCLUSIONS: These data indicate that the pharmacological 
      effects of MDMA are robust and highly reproducible across settings. There was 
      also modest evidence for tolerance to the effects of MDMA in regular users.
FAU - Kirkpatrick, Matthew G
AU  - Kirkpatrick MG
AD  - Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 
      S. Maryland Ave., MC 3077, Chicago, IL, 60637, USA.
FAU - Baggott, Matthew J
AU  - Baggott MJ
FAU - Mendelson, John E
AU  - Mendelson JE
FAU - Galloway, Gantt P
AU  - Galloway GP
FAU - Liechti, Matthias E
AU  - Liechti ME
FAU - Hysek, Cedric M
AU  - Hysek CM
FAU - de Wit, Harriet
AU  - de Wit H
LA  - eng
GR  - DA02812/DA/NIDA NIH HHS/United States
GR  - R21 DA026570/DA/NIDA NIH HHS/United States
GR  - DA026570/DA/NIDA NIH HHS/United States
GR  - R01 DA002812/DA/NIDA NIH HHS/United States
GR  - DA017716/DA/NIDA NIH HHS/United States
GR  - UL1 TR000430/TR/NCATS NIH HHS/United States
GR  - R01 DA016776/DA/NIDA NIH HHS/United States
GR  - DA016776/DA/NIDA NIH HHS/United States
GR  - R01 DA017716/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140315
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Blood Pressure/*drug effects/physiology
MH  - Double-Blind Method
MH  - Female
MH  - Heart Rate/*drug effects/physiology
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Reproducibility of Results
MH  - Young Adult
PMC - PMC4161650
MID - NIHMS575897
EDAT- 2014/03/19 06:00
MHDA- 2015/09/01 06:00
PMCR- 2015/10/01
CRDT- 2014/03/18 06:00
PHST- 2014/01/17 00:00 [received]
PHST- 2014/02/26 00:00 [accepted]
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - 10.1007/s00213-014-3528-z [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2014 Oct;231(19):3899-905. doi: 
      10.1007/s00213-014-3528-z. Epub 2014 Mar 15.