PMID- 24633588
OWN - NLM
STAT- MEDLINE
DCOM- 20150831
LR  - 20161125
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 406
IP  - 21
DP  - 2014 Aug
TI  - Determination of lewisite constituents in aqueous samples using hollow-fibre 
      liquid-phase microextraction followed by gas chromatography-mass spectrometry.
PG  - 5103-10
LID - 10.1007/s00216-014-7751-6 [doi]
AB  - The applicability of hollow-fibre liquid-phase microextraction for extracting 
      2-chlorovinyldichloroarsine (lewisite 1), bis(2-chlorovinyl)chloroarsine 
      (lewisite 2), tris(2-chlorovinyl)arsine (lewisite 3) and arsenic trichloride from 
      aqueous samples is reported. Parameters affecting the extraction efficiency of 
      these chemicals were optimised. These parameters included the type of 
      derivatising agent, extraction solvent, derivatisation method, pH, ionic 
      strength, stirring speed and extraction time. A linear range between 0.002 and 
      0.2 mug/mL was established for the lewisites with good square regression 
      coefficients (0.9955-0.9992). Good reproducibility with relative standard 
      deviations (RSDs) from 8 to 10% was achieved. The limit of detection was 0.002 
      mug/mL for the lewisites and 0.005 mug/mL for arsenic trichloride (3:1 
      signal-to-noise ratio). The extraction method was validated with a proficiency 
      test sample issued by the Organisation for the Prohibition of Chemical Weapons 
      (OPCW). The rapidity and precision of the new method should help deter against 
      the employment of lewisite as a chemical warfare agent: its use could be 
      confirmed easily from analysis of aqueous samples.
FAU - Cheh, M Y
AU  - Cheh MY
AD  - DSO National Laboratories, 20 Science Park Drive, Singapore, 118230, Singapore, 
      cmeiyee@dso.org.sg.
FAU - Chua, H C
AU  - Chua HC
FAU - Hopkins, F B
AU  - Hopkins FB
FAU - Riches, J R
AU  - Riches JR
FAU - Timperley, C M
AU  - Timperley CM
FAU - Lee, H S Nancy
AU  - Lee HS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140318
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Arsenicals)
RN  - 0 (Chemical Warfare Agents)
RN  - 0 (Chlorides)
RN  - 0 (Sulfhydryl Compounds)
RN  - 0 (Water Pollutants, Chemical)
RN  - 059QF0KO0R (Water)
RN  - 0N54LGU5WS (lewisite)
RN  - 5XW39M1300 (arsenic trichloride)
SB  - IM
MH  - Arsenicals/*isolation & purification
MH  - Chemical Warfare Agents/*isolation & purification
MH  - Chlorides/*isolation & purification
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Laboratory Proficiency Testing
MH  - Limit of Detection
MH  - Liquid Phase Microextraction/methods
MH  - Osmolar Concentration
MH  - Reproducibility of Results
MH  - Signal-To-Noise Ratio
MH  - Sulfhydryl Compounds/*chemistry
MH  - Water/chemistry
MH  - Water Pollutants, Chemical/*isolation & purification
EDAT- 2014/03/19 06:00
MHDA- 2015/09/01 06:00
CRDT- 2014/03/18 06:00
PHST- 2013/12/11 00:00 [received]
PHST- 2014/03/05 00:00 [accepted]
PHST- 2014/02/25 00:00 [revised]
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
AID - 10.1007/s00216-014-7751-6 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2014 Aug;406(21):5103-10. doi: 10.1007/s00216-014-7751-6. Epub 
      2014 Mar 18.