PMID- 24634792
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140317
LR  - 20211021
IS  - 2090-9446 (Print)
IS  - 2090-9446 (Electronic)
IS  - 2090-9446 (Linking)
VI  - 2013
DP  - 2013
TI  - Adipokines, oxidized low-density lipoprotein, and C-reactive protein levels in 
      lean, overweight, and obese portuguese patients with type 2 diabetes.
PG  - 142097
LID - 10.1155/2013/142097 [doi]
LID - 142097
AB  - Aim. Our aim was to study how different BMI scores may influence the levels of 
      inflammation, oxidative stress, adipogenesis, glucose, and lipid metabolism, in 
      lean, overweight, and obese Portuguese patients with type 2 diabetes mellitus 
      (T2DM). Methods. We studied 28 lean, 38 overweight, and 17 obese patients with 
      T2DM and 20 controls (gender and age matched). The circulating levels of oxLDL, 
      CRP, and some adipokines-adiponectin, leptin, and chemerin-and the lipid profile 
      were evaluated. Results. Obese patients presented significantly lower levels of 
      adiponectin and higher leptin, oxLDL, and chemerin levels, as compared to the 
      overweight, lean, and control groups. Overweight, compared to lean and control, 
      subjects showed significantly lower adiponectin and higher leptin and chemerin 
      levels; oxLDL values were significantly higher in overweight than in lean 
      patients. Lean patients presented significantly higher chemerin values than the 
      control. Obese patients presented significantly higher CRP values, as compared to 
      lean patients and the control group. Obese and overweight patients presented 
      significantly higher triglycerides values than lean patients. Except for CRP, all 
      the observed significant changes between control and patients remained 
      significant after statistical adjustment for the body mass index (BMI). 
      Conclusion. The levels of leptin, adiponectin, oxLDL, CRP, and triglycerides in 
      patients with T2DM seem to be more associated with obesity and less with 
      diabetes. Chemerin levels were raised in lean, overweight, and obese patients, 
      suggesting that, independently of BMI, an adipocyte dysfunction occurs. Moreover, 
      chemerin may provide an important early biomarker of adipocyte dysfunction and a 
      link between obesity and type 2 diabetes mellitus.
FAU - Neuparth, Maria Joao
AU  - Neuparth MJ
AD  - Centro de Investigacao em Actividade Fisica, Saude e Lazer, Universidade do 
      Porto, Rua Dr. Placido Costa 91, 4200-450 Porto, Portugal ; Centro de 
      Investigacao das Tecnologias da Saude (CITS), Instituto Politecnico da Saude do 
      Norte (IPSN), Cooperativa de Ensino Superior, Politecnico e Universitario 
      (CESPU), Rua Jose Antonio Vidal 81, 4760-409 Vila Nova de Famalicao, Portugal.
FAU - Proenca, Jorge Brandao
AU  - Proenca JB
AD  - Instituto Superior de Ciencias da Saude Norte (ISCS-N), CESPU, Rua Central de 
      Gandra 1317, 4585-116 Gandra, Portugal.
FAU - Santos-Silva, Alice
AU  - Santos-Silva A
AD  - Laboratorio de Bioquimica, Departamento de Ciencias Biologicas, Faculdade de 
      Farmacia, Universidade do Porto, Rua de Jorge Viterbo 228, 4050-313 Porto, 
      Portugal ; Instituto de Biologia Molecular e Celular (IBMC), Universidade do 
      Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal.
FAU - Coimbra, Susana
AU  - Coimbra S
AD  - Centro de Investigacao das Tecnologias da Saude (CITS), Instituto Politecnico da 
      Saude do Norte (IPSN), Cooperativa de Ensino Superior, Politecnico e 
      Universitario (CESPU), Rua Jose Antonio Vidal 81, 4760-409 Vila Nova de 
      Famalicao, Portugal ; Instituto de Biologia Molecular e Celular (IBMC), 
      Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20130117
PL  - United States
TA  - ISRN Obes
JT  - ISRN obesity
JID - 101607056
PMC - PMC3901968
EDAT- 2013/01/01 00:00
MHDA- 2013/01/01 00:01
PMCR- 2013/01/17
CRDT- 2014/03/18 06:00
PHST- 2012/10/19 00:00 [received]
PHST- 2012/11/26 00:00 [accepted]
PHST- 2014/03/18 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2013/01/01 00:01 [medline]
PHST- 2013/01/17 00:00 [pmc-release]
AID - 10.1155/2013/142097 [doi]
PST - epublish
SO  - ISRN Obes. 2013 Jan 17;2013:142097. doi: 10.1155/2013/142097. eCollection 2013.