PMID- 24635063
OWN - NLM
STAT- MEDLINE
DCOM- 20150106
LR  - 20221207
IS  - 1365-2230 (Electronic)
IS  - 0307-6938 (Linking)
VI  - 39
IP  - 3
DP  - 2014 Apr
TI  - Therapeutic outcome of melasma treatment by dual-wavelength (511 and 578 nm) 
      laser in patients with skin phototypes III-V.
PG  - 292-7
LID - 10.1111/ced.12267 [doi]
AB  - BACKGROUND: Recent evidence suggests that vascular abnormalities are involved in 
      the pathogenesis of melasma. Copper bromide (CuBr) laser, which emits dual 
      wavelengths (511 and 578 nm), enabling simultaneous and selective destruction of 
      melanin-containing cells and blood vessels, may be of benefit in the treatment of 
      melasma. AIM: To investigate the efficacy and adverse effects (AEs) of CuBr laser 
      for melasma treatment in patients with skin phototypes III-V. METHODS: We 
      enrolled 24 Thai women with melasma to receive six CuBr laser treatments, 2 weeks 
      apart. Objective (colour measurement) and subjective (clinical evaluation of 
      photographs by three dermatologists blinded to the order of the photographs) 
      assessments were obtained at baseline, after three and six treatments, and at the 
      3-month follow-up visit. A visual analogue scale (VAS) was used for patient 
      assessment of change at baseline, after six treatments and at the 3-month 
      follow-up. AEs were recorded at every follow-up visit. RESULTS: Of the 24 
      patients, 20 completed the study. Mean melanin index (MI) showed no statistically 
      significant improvement compared with baseline measurements at any of the 
      follow-up visits. There were significant improvements in clinical evaluation 
      after three treatments (P = 0.00); however, this difference was no longer visible 
      after six treatments. At follow-up 1 week after the end of the full course of six 
      treatments, there was an improvement in VAS (P = 0.02). However, there was no 
      improvement as measured by clinical evaluation or MI. Mild, transient AEs 
      including erythema, burning sensation, scaling, hyperpigmentation and crusting 
      were noted. CONCLUSIONS: CuBr laser did not show effectiveness in improving 
      melasma in patients with skin phototypes III-V.
CI  - (c) 2014 British Association of Dermatologists.
FAU - Eimpunth, S
AU  - Eimpunth S
AD  - Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Wanitphakdeedecha, R
AU  - Wanitphakdeedecha R
FAU - Triwongwaranat, D
AU  - Triwongwaranat D
FAU - Varothai, S
AU  - Varothai S
FAU - Manuskiatti, W
AU  - Manuskiatti W
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Dermatol
JT  - Clinical and experimental dermatology
JID - 7606847
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Facial Dermatoses/*radiotherapy
MH  - Female
MH  - Humans
MH  - Lasers, Gas/therapeutic use
MH  - Low-Level Light Therapy/adverse effects/*methods
MH  - Melanosis/*radiotherapy
MH  - Middle Aged
MH  - Thailand
MH  - Young Adult
EDAT- 2014/03/19 06:00
MHDA- 2015/01/07 06:00
CRDT- 2014/03/19 06:00
PHST- 2013/10/15 00:00 [accepted]
PHST- 2014/03/19 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/01/07 06:00 [medline]
AID - 10.1111/ced.12267 [doi]
PST - ppublish
SO  - Clin Exp Dermatol. 2014 Apr;39(3):292-7. doi: 10.1111/ced.12267.