PMID- 24635401
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20160307
IS  - 1784-3286 (Print)
IS  - 1784-3286 (Linking)
VI  - 69
IP  - 1
DP  - 2014 Jan-Feb
TI  - Severe symptomatic hypomagnesaemia induced by the chronic use of proton pump 
      inhibitors: a case report of a patient with Zollinger-Ellison syndrome.
PG  - 62-5
LID - 10.1179/0001551213Z.0000000008 [doi]
AB  - The association between proton pump inhibitor (PPI) therapy and hypomagnesaemia 
      has been recognized since 2006. We report the case of a 51-year-old woman who 
      developed severe symptomatic hypomagnesaemia after a long-term PPI therapy given 
      for recurrent peptic ulcer disease. Hypomagnesaemia could only partially be 
      resolved during substitution therapy, but was corrected after withdrawal of the 
      PPI. Recurrence of hypomagnesaemia occurred after retreatment with PPIs, 
      supporting the causal relationship. An underlying gastric acid hypersecretion 
      (Zollinger-Ellison syndrome) was highly suspected and eventually controlled by a 
      combination of a histamine 2-receptor antagonist and octreotide, without the need 
      for further PPI therapy after 2 years of follow-up.
FAU - Stroker, E
AU  - Stroker E
FAU - Leone, L
AU  - Leone L
FAU - Vandeput, Y
AU  - Vandeput Y
FAU - Borbath, I
AU  - Borbath I
FAU - Lefebvre, C
AU  - Lefebvre C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Acta Clin Belg
JT  - Acta clinica Belgica
JID - 0370306
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Blood Chemical Analysis
MH  - Female
MH  - Humans
MH  - Magnesium Deficiency/*chemically induced
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Zollinger-Ellison Syndrome/*drug therapy
OTO - NOTNLM
OT  - Hypomagnesaemia,
OT  - Proton pump inhibitor,
OT  - Zollinger-Ellison syndrome
EDAT- 2014/03/19 06:00
MHDA- 2014/04/25 06:00
CRDT- 2014/03/19 06:00
PHST- 2014/03/19 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
AID - 10.1179/0001551213Z.0000000008 [doi]
PST - ppublish
SO  - Acta Clin Belg. 2014 Jan-Feb;69(1):62-5. doi: 10.1179/0001551213Z.0000000008.