PMID- 24636251 OWN - NLM STAT- MEDLINE DCOM- 20150402 LR - 20220309 IS - 1471-4981 (Electronic) IS - 1471-4906 (Linking) VI - 35 IP - 4 DP - 2014 Apr TI - Microglia fuel the learning brain. PG - 139-40 LID - S1471-4906(14)00030-1 [pii] LID - 10.1016/j.it.2014.02.005 [doi] AB - Microglia, the brain resident macrophages, are first responders to any violation of central nervous system (CNS) homeostasis. A recent paper in Cell shows that the specific depletion of microglia causes deficits in learning-induced synaptic remodeling through paucity of the microglial neurotrophin brain-derived neurotrophic factor (BDNF). CI - Copyright (c) 2014 Elsevier Ltd. All rights reserved. FAU - Blank, Thomas AU - Blank T AD - Institute of Neuropathology, University of Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany. FAU - Goldmann, Tobias AU - Goldmann T AD - Institute of Neuropathology, University of Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany. FAU - Prinz, Marco AU - Prinz M AD - Institute of Neuropathology, University of Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Germany. Electronic address: marco.prinz@uniklinik-freiburg.de. LA - eng PT - Journal Article PT - Review DEP - 20140311 PL - England TA - Trends Immunol JT - Trends in immunology JID - 100966032 SB - IM MH - Animals MH - Brain/*cytology/*physiology MH - Humans MH - Microglia/*cytology/*physiology EDAT- 2014/03/19 06:00 MHDA- 2015/04/04 06:00 CRDT- 2014/03/19 06:00 PHST- 2014/02/16 00:00 [received] PHST- 2014/02/17 00:00 [accepted] PHST- 2014/03/19 06:00 [entrez] PHST- 2014/03/19 06:00 [pubmed] PHST- 2015/04/04 06:00 [medline] AID - S1471-4906(14)00030-1 [pii] AID - 10.1016/j.it.2014.02.005 [doi] PST - ppublish SO - Trends Immunol. 2014 Apr;35(4):139-40. doi: 10.1016/j.it.2014.02.005. Epub 2014 Mar 11.