PMID- 24636743
OWN - NLM
STAT- MEDLINE
DCOM- 20150102
LR  - 20181202
IS  - 1618-095X (Electronic)
IS  - 0944-7113 (Linking)
VI  - 21
IP  - 6
DP  - 2014 May 15
TI  - Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic 
      seizures via IL-1beta and brain-derived neurotrophic factor.
PG  - 893-900
LID - S0944-7113(14)00033-6 [pii]
LID - 10.1016/j.phymed.2014.01.011 [doi]
AB  - Uncaria rhynchophylla (UR) has been used for the treatment of convulsions and 
      epilepsy in traditional Chinese medicine. This study reported the major 
      anti-convulsive signaling pathways and effective targets of UR and 
      rhynchophylline (RP) using genomic and immunohistochemical studies. Epileptic 
      seizure model was established by intraperitoneal injection of kainic acid (KA) in 
      rats. Electroencephalogram and electromyogram recordings indicated that UR and RP 
      improved KA-induced epileptic seizures. Toll-like receptor (TLR) and neurotrophin 
      signaling pathways were regulated by UR in both cortex and hippocampus of 
      KA-treated rats. KA upregulated the expression levels of interleukin-1beta (IL-1beta) 
      and brain-derived neurotrophin factor (BDNF), which were involved in TLR and 
      neurotrophin signaling pathways, respectively. However, UR and RP downregulated 
      the KA-induced IL-1beta and BDNF gene expressions. Our findings suggested that UR 
      and RP exhibited anti-convulsive effects in KA-induced rats via the regulation of 
      TLR and neurotrophin signaling pathways, and the subsequent inhibition of IL-1beta 
      and BDNF gene expressions.
CI  - Copyright (c) 2014 Elsevier GmbH. All rights reserved.
FAU - Ho, Tin-Yun
AU  - Ho TY
AD  - Graduate Institute of Chinese Medicine, College of Chinese Medicine, China 
      Medical University, Taichung 40402, Taiwan.
FAU - Tang, Nou-Ying
AU  - Tang NY
AD  - School of Chinese Medicine, College of Chinese Medicine, China Medical 
      University, Taichung 40402, Taiwan.
FAU - Hsiang, Chien-Yun
AU  - Hsiang CY
AD  - Department of Microbiology, College of Medicine, China Medical University, 
      Taichung 40402, Taiwan.
FAU - Hsieh, Ching-Liang
AU  - Hsieh CL
AD  - Graduate Institute of Integrated Medicine, College of Chinese Medicine, China 
      Medical University, Taichung 40402, Taiwan; Acupuncture Research Center, China 
      Medical University, Taichung 40402, Taiwan; Department of Chinese Medicine, China 
      Medical University Hospital, Taichung 40402, Taiwan. Electronic address: 
      clhsieh@mail.cmu.org.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140311
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Indole Alkaloids)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Oxindoles)
RN  - 0 (Plant Extracts)
RN  - 0 (Toll-Like Receptors)
RN  - 46BQ79VJ8D (rhyncophylline)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Epilepsy/chemically induced/*drug therapy/metabolism
MH  - Gene Expression/drug effects
MH  - Indole Alkaloids/pharmacology/*therapeutic use
MH  - Interleukin-1beta/*metabolism
MH  - Kainic Acid
MH  - Male
MH  - Oxindoles
MH  - *Phytotherapy
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - Rats, Sprague-Dawley
MH  - Toll-Like Receptors/metabolism
MH  - Uncaria/*chemistry
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Epileptic seizure
OT  - Interleukin-1beta
OT  - Rhynchophylline
OT  - Uncaria rhynchophylla
EDAT- 2014/03/19 06:00
MHDA- 2015/01/03 06:00
CRDT- 2014/03/19 06:00
PHST- 2013/07/23 00:00 [received]
PHST- 2013/11/08 00:00 [revised]
PHST- 2014/01/31 00:00 [accepted]
PHST- 2014/03/19 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/01/03 06:00 [medline]
AID - S0944-7113(14)00033-6 [pii]
AID - 10.1016/j.phymed.2014.01.011 [doi]
PST - ppublish
SO  - Phytomedicine. 2014 May 15;21(6):893-900. doi: 10.1016/j.phymed.2014.01.011. Epub 
      2014 Mar 11.