PMID- 24637128
OWN - NLM
STAT- MEDLINE
DCOM- 20150107
LR  - 20191210
IS  - 1873-5126 (Electronic)
IS  - 1353-8020 (Linking)
VI  - 20
IP  - 5
DP  - 2014 May
TI  - Hyposmia and cardiovascular dysautonomia correlatively appear in early-stage 
      Parkinson's disease.
PG  - 520-4
LID - S1353-8020(14)00063-7 [pii]
LID - 10.1016/j.parkreldis.2014.02.010 [doi]
AB  - OBJECTIVE: Olfactory dysfunction is considered to precede motor symptoms and 
      early markers of Parkinson's disease (PD), while the relative time at which 
      cardiovascular dysautonomia appears in PD is not well understood. To assess the 
      appearance of cardiovascular dysautonomia in PD, we evaluated its relation to 
      olfactory dysfunction in early-stage PD patients. METHODS: Twenty-three 
      non-demented PD patients within 2 years from the onset of motor symptoms were 
      enrolled. We evaluated olfactory dysfunction by the Odor Stick Identification 
      Test for Japanese (OSIT-J) and analyzed its relationship to the results of other 
      cardiovascular autonomic tests and cardiac (123)I-metaiodobenzylguanidine (MIBG) 
      scintigraphy. RESULTS: There was a correlation between olfactory scores and 
      increased blood pressure in both the norepinephrine (r = 0.75, p < 0.0001, 
      n = 21) and dobutamine (r = 0.57, p = 0.0087, n = 20) infusion tests and cardiac 
      MIBG uptake (r = 0.42, p = 0.049, n = 23). The fall in orthostatic blood pressure 
      during the head-up tilt test was not correlated with the olfactory scores, but 
      the Valsalva maneuver revealed that OSIT-J scores correlated with the pressure 
      recovery time from phase III to the return of blood pressure to baseline 
      (r = 0.54, p = 0.037, n = 15) and with the magnitude of blood pressure overshoot 
      during phase IV (r = 0.67, p = 0.0016, n = 20). CONCLUSION: Our results 
      demonstrate that extensive components of the cardiovascular sympathetic system as 
      well as the olfactory system are correlatively impaired in the early stage of PD, 
      suggesting that degeneration of broad aspects of the cardiovascular sympathetic 
      system occurs concurrently with olfactory system degeneration during the premotor 
      phase of PD.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Mizutani, Yasuaki
AU  - Mizutani Y
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Nakamura, Tomohiko
AU  - Nakamura T
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan; Department of Laboratory Medicine, Nagoya University Hospital, Nagoya, 
      Japan.
FAU - Okada, Akinori
AU  - Okada A
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Suzuki, Junichiro
AU  - Suzuki J
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Watanabe, Hirohisa
AU  - Watanabe H
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Hirayama, Masaaki
AU  - Hirayama M
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan; Department of Pathophysiological Laboratory Sciences, Nagoya University 
      Graduate School of Medicine, Nagoya, Japan.
FAU - Sobue, Gen
AU  - Sobue G
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan. Electronic address: sobueg@med.nagoya-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20140220
PL  - England
TA  - Parkinsonism Relat Disord
JT  - Parkinsonism & related disorders
JID - 9513583
RN  - 0 (Guanidines)
RN  - 0 (Iodine Isotopes)
RN  - 2211-57-6 (benzylguanidine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Autonomic Nervous System Diseases/complications/*etiology
MH  - Cardiovascular Diseases/complications/*etiology
MH  - Discrimination, Psychological/physiology
MH  - Female
MH  - Guanidines
MH  - Humans
MH  - Iodine Isotopes
MH  - Male
MH  - Middle Aged
MH  - Odorants
MH  - Olfaction Disorders/diagnosis/*etiology
MH  - Parkinson Disease/*complications
MH  - Smell/physiology
MH  - Valsalva Maneuver/physiology
OTO - NOTNLM
OT  - Cardiac (123)I-metaiodobenzylguanidine scintigraphy
OT  - Cardiovascular dysautonomia
OT  - OSIT-J
OT  - Olfactory dysfunction
OT  - Parkinson's disease
EDAT- 2014/03/19 06:00
MHDA- 2015/01/08 06:00
CRDT- 2014/03/19 06:00
PHST- 2013/10/01 00:00 [received]
PHST- 2014/02/08 00:00 [revised]
PHST- 2014/02/12 00:00 [accepted]
PHST- 2014/03/19 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/01/08 06:00 [medline]
AID - S1353-8020(14)00063-7 [pii]
AID - 10.1016/j.parkreldis.2014.02.010 [doi]
PST - ppublish
SO  - Parkinsonism Relat Disord. 2014 May;20(5):520-4. doi: 
      10.1016/j.parkreldis.2014.02.010. Epub 2014 Feb 20.