PMID- 24637399
OWN - NLM
STAT- MEDLINE
DCOM- 20150102
LR  - 20211021
IS  - 1949-1042 (Electronic)
IS  - 1949-1034 (Print)
IS  - 1949-1034 (Linking)
VI  - 5
IP  - 1
DP  - 2014 Jan-Feb
TI  - The fine line between lifespan extension and shortening in response to caloric 
      restriction.
PG  - 56-65
LID - 10.4161/nucl.27929 [doi]
AB  - Caloric restriction (CR) is generally linked to lifespan extension in various 
      organisms and may limit age-associated diseases. Processes through which caloric 
      restriction promotes lifespan include obesity-countering weight loss, increased 
      DNA repair, control of ribosomal and telomeric DNA repeats, mitochondrial 
      regulation, activation of antioxidants, and protective autophagy. Several of 
      these protective cellular processes are linked to the suppression of TOR (target 
      of rapamycin) or the activation of sirtuins. In stark contrast, CR fails to 
      extend or even shortens lifespan in certain settings. CR-dependent lifespan 
      shortening is linked to weight loss in the non-obese, mitochondrial 
      hyperactivity, genomic inflexibility, and several other processes. Deciphering 
      the balance between positive and negative effects of CR is critical to 
      understanding its ultimate impact on aging. This knowledge is especially needed 
      in order to fulfil the promise of using CR or its mimetic drugs to counteract 
      age-associated diseases and unhealthy aging.
FAU - Szafranski, Kirk
AU  - Szafranski K
AD  - Department of Laboratory Medicine and Pathobiology; Faculty of Medicine, 
      University of Toronto; Toronto, ON Canada.
FAU - Mekhail, Karim
AU  - Mekhail K
AD  - Department of Laboratory Medicine and Pathobiology; Faculty of Medicine, 
      University of Toronto; Toronto, ON Canada; Canada Research Chairs Program; 
      Faculty of Medicine, University of Toronto; Toronto, ON Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140127
PL  - United States
TA  - Nucleus
JT  - Nucleus (Austin, Tex.)
JID - 101518322
RN  - 0 (Micronutrients)
RN  - EC 3.5.1.- (Sirtuins)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - DNA Repair/*physiology
MH  - Energy Metabolism/physiology
MH  - Genomic Instability/physiology
MH  - Humans
MH  - Longevity/*physiology
MH  - Micronutrients/blood
MH  - Models, Animal
MH  - Oxidative Stress/physiology
MH  - Ribosomes/metabolism
MH  - Sirtuins/genetics/metabolism
MH  - Weight Loss
PMC - PMC4028356
OTO - NOTNLM
OT  - TOR
OT  - autophagy
OT  - caloric restriction
OT  - genome stability
OT  - oxidative stress
OT  - sirtuins
EDAT- 2014/03/19 06:00
MHDA- 2015/01/03 06:00
PMCR- 2015/01/01
CRDT- 2014/03/19 06:00
PHST- 2014/03/19 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/01/03 06:00 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 27929 [pii]
AID - 2013NUCLEUS0076R [pii]
AID - 10.4161/nucl.27929 [doi]
PST - ppublish
SO  - Nucleus. 2014 Jan-Feb;5(1):56-65. doi: 10.4161/nucl.27929. Epub 2014 Jan 27.