PMID- 24637473
OWN - NLM
STAT- MEDLINE
DCOM- 20150402
LR  - 20150729
IS  - 1827-1898 (Electronic)
IS  - 0031-0808 (Linking)
VI  - 56
IP  - 1
DP  - 2014 Mar
TI  - Decreasing efficacy of the standard seven-day triple therapy containing 
      amoxycillin and clarithromycin in curing Helicobacter pylori infection in 
      clinical setting in Italy: a 10-year follow-up study.
PG  - 57-61
AB  - AIM: The aim of the present study was to assess the efficacy of the standard 
      triple therapy containing PPI plus amoxycillin and clarithromycin in curing 
      Helicobacter pylori (H. pylori) infection during a long-term period. METHODS: A 
      retrospective analysis was conducted on 1497 consecutive dyspeptic patients with 
      proven H. pylori infection and enrolled from 1996 to 2006. Patients received a 
      standard triple therapy with proton pump inhibitor (PPI) plus amoxicillin 1 g and 
      clarithromycin 500 mg for 7 days (all twice daily) plus PPI every day for further 
      4 weeks in case of active peptic ulcer or severe gastritis detected at endoscopy. 
      One month after conclusion of therapy, endoscopy was performed in those patients 
      for whom the examinations were clinically relevant. The remaining patients were 
      checked by (1)(3)C-urea breath test. RESULTS: The overall H. pylori eradication rate 
      was 70.41% (on intention-to-treat analysis). However, it decreased significantly 
      during the observation period, ranging from 90% (95% CI 87.14% to 93.91%) in 1996 
      to 51.11% (95% CI 48.14% to 55.91%) in 2006 (on i-t-t analysis) (P=0.001). No 
      difference in eradicating the was found infection between Puglia and Lazio (1996: 
      P=0.39; 2006: P=0.64). CONCLUSION: Standard triple therapy does not appear 
      anymore a valid therapeutic strategy for the management of H. pylori infection in 
      clinical practice.
FAU - Tursi, A
AU  - Tursi A
AD  - Gastroenterology Service, ASL BAT, Andria, Barletta-Andria-Trani, Italy - 
      antotursi@tiscali.it.
FAU - Elisei, W
AU  - Elisei W
FAU - Giorgetti, G
AU  - Giorgetti G
FAU - Picchio, M
AU  - Picchio M
FAU - Brandimarte, G
AU  - Brandimarte G
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Panminerva Med
JT  - Panminerva medica
JID - 0421110
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - 804826J2HU (Amoxicillin)
RN  - H1250JIK0A (Clarithromycin)
SB  - IM
CIN - Panminerva Med. 2015 Sep;57(3):145-6. PMID: 25971330
MH  - Adult
MH  - Aged
MH  - Amoxicillin/*administration & dosage
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Breath Tests
MH  - Clarithromycin/*administration & dosage
MH  - Drug Administration Schedule
MH  - Endoscopy
MH  - Female
MH  - Follow-Up Studies
MH  - Gastritis/drug therapy
MH  - Helicobacter Infections/*drug therapy
MH  - *Helicobacter pylori
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Peptic Ulcer/drug therapy
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2014/03/19 06:00
MHDA- 2015/04/04 06:00
CRDT- 2014/03/19 06:00
PHST- 2014/03/19 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/04/04 06:00 [medline]
AID - R41Y2014N01A0057 [pii]
PST - ppublish
SO  - Panminerva Med. 2014 Mar;56(1):57-61.