PMID- 24639245
OWN - NLM
STAT- MEDLINE
DCOM- 20150416
LR  - 20200109
IS  - 1432-069X (Electronic)
IS  - 0340-3696 (Linking)
VI  - 306
IP  - 6
DP  - 2014 Aug
TI  - Association between an HLA-G 14 bp insertion/deletion polymorphism and 
      non-segmental vitiligo in the Korean population.
PG  - 577-82
LID - 10.1007/s00403-014-1459-5 [doi]
AB  - Vitiligo is a pigmentary skin disorder characterized by the chronic and 
      progressive loss of melanocytes. Although the etiology of vitiligo is still 
      unknown, several theories have been proposed to explain the pathogenesis of 
      vitiligo including autoimmune, neural, self-destruction, oxidative stress, and 
      genetic theories. Human leukocyte antigen (HLA)-G is a nonclassic, major 
      histocompatibility complex class I molecule that plays an important role in 
      suppression of the immune response. Several recent studies have provided evidence 
      that a 14 bp insertion (INS)/deletion (DEL) polymorphism in the HLA-G gene might 
      be associated with autoimmune disease. Our aim in this study was to determine 
      whether the 14 bp INS/DEL polymorphism in the HLA-G gene contributes to the risk 
      of developing non-segmental vitiligo (NSV) in the Korean population. We conducted 
      a case-control association study of 192 NSV patients and 491 matched, unaffected 
      controls. The HLA-G 14bp INS/DEL polymorphism was analyzed by gene scan after 
      amplification using the polymerase chain reaction. Genotype frequencies for the 
      14bpINS/DEL were different between the vitiligo group and Korean control group. 
      The proportion of subjects with a homozygote 14bpINS/14bpINS genotype was 
      significantly higher in the vitiligo group compared with the control group (7.1 
      vs. 3.5 %, OR 2.25, 95 % CI 1.06-4.76, p = 0.039 in the recessive model). Our 
      results suggest that the HLA-G 14bpINS/DEL polymorphism is associated with the 
      development of NSV in the Korean population.
FAU - Jeong, K-H
AU  - Jeong KH
AD  - Department of Dermatology, College of Medicine, Kyung Hee University, #1 
      Hoegi-dong, Dongdaemun-gu, Seoul, 130-702, Korea.
FAU - Kim, S-K
AU  - Kim SK
FAU - Kang, B-K
AU  - Kang BK
FAU - Chung, J-H
AU  - Chung JH
FAU - Shin, M-K
AU  - Shin MK
FAU - Lee, M-H
AU  - Lee MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140318
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-G Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Mutagenesis, Insertional/*genetics
MH  - Polymorphism, Genetic
MH  - Republic of Korea
MH  - Sequence Deletion/*genetics
MH  - Vitiligo/*genetics
EDAT- 2014/03/19 06:00
MHDA- 2015/04/17 06:00
CRDT- 2014/03/19 06:00
PHST- 2013/10/30 00:00 [received]
PHST- 2014/02/18 00:00 [accepted]
PHST- 2014/02/11 00:00 [revised]
PHST- 2014/03/19 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2015/04/17 06:00 [medline]
AID - 10.1007/s00403-014-1459-5 [doi]
PST - ppublish
SO  - Arch Dermatol Res. 2014 Aug;306(6):577-82. doi: 10.1007/s00403-014-1459-5. Epub 
      2014 Mar 18.