PMID- 24639398
OWN - NLM
STAT- MEDLINE
DCOM- 20141105
LR  - 20220330
IS  - 1097-0339 (Electronic)
IS  - 8755-1039 (Print)
IS  - 1097-0339 (Linking)
VI  - 42
IP  - 4
DP  - 2014 Apr
TI  - Utilization of ancillary studies in the cytologic diagnosis of biliary and 
      pancreatic lesions: the Papanicolaou Society of Cytopathology guidelines for 
      pancreatobiliary cytology.
PG  - 351-62
LID - 10.1002/dc.23093 [doi]
AB  - The Papanicolaou Society of Cytopathology has developed a set of guidelines for 
      pancreatobiliary cytology including indications for endoscopic ultrasound-guided 
      fine-needle aspiration, terminology and nomenclature of pancreatobiliary disease, 
      ancillary testing, and post-biopsy management. All documents are based on the 
      expertise of the authors, a review of the literature, discussions of the draft 
      document at several national and international meetings, and synthesis of 
      selected online comments of the draft document. This document presents the 
      results of these discussions regarding the use of ancillary testing in the 
      cytologic diagnosis of biliary and pancreatic lesions. Currently, fluorescence in 
      situ hybridization (FISH) appears to be the most clinically relevant ancillary 
      technique for cytology of bile duct strictures. The addition of FISH analysis to 
      routine cytologic evaluation appears to yield the highest sensitivity without 
      loss in specificity. Loss of immunohistochemical staining for the protein product 
      of the SMAD4 gene and positive staining for mesothelin support a diagnosis of 
      ductal adenocarcinoma. Immunohistochemical markers for endocrine and exocrine 
      differentiation are sufficient for a diagnosis of endocrine and acinar tumors. 
      Nuclear staining for beta-catenin supports a diagnosis of solid-pseudopapilary 
      neoplasm. Cyst fluid analysis for amylase and carcinoembryonic antigen aids in 
      the preoperative classification of pancreatic cysts. Many gene mutations (KRAS, 
      GNAS, VHL, RNF43, and CTNNB1) may be of aid in the diagnosis of cystic neoplasms. 
      Other ancillary techniques do not appear to improve diagnostic sensitivity 
      sufficiently to justify their increased costs.
CI  - Copyright (c) 2014 Wiley Periodicals, Inc.
FAU - Layfield, Lester J
AU  - Layfield LJ
AD  - Department of Pathology and Anatomical Sciences, University of Missouri, 
      Columbia, Missouri.
FAU - Ehya, Hormoz
AU  - Ehya H
FAU - Filie, Armando C
AU  - Filie AC
FAU - Hruban, Ralph H
AU  - Hruban RH
FAU - Jhala, Nirag
AU  - Jhala N
FAU - Joseph, Loren
AU  - Joseph L
FAU - Vielh, Philippe
AU  - Vielh P
FAU - Pitman, Martha B
AU  - Pitman MB
CN  - Papanicolaou Society of Cytopathology
LA  - eng
GR  - P30 CA006973/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Practice Guideline
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
SB  - IM
MH  - Bile Duct Neoplasms/*diagnosis/genetics/pathology
MH  - Bile Ducts/*pathology
MH  - Constriction, Pathologic
MH  - Cytodiagnosis/*methods
MH  - Humans
MH  - Pancreas/*pathology
MH  - Pancreatic Ducts/pathology
MH  - Pancreatic Neoplasms/*diagnosis/genetics/pathology
MH  - *Societies, Medical
PMC - PMC4313905
MID - NIHMS658994
OTO - NOTNLM
OT  - EUS
OT  - ancillary studies
OT  - biliary tract
OT  - fine-needle aspiration
OT  - molecular diagnosis
OT  - pancreas
EDAT- 2014/03/19 06:00
MHDA- 2014/11/06 06:00
PMCR- 2015/02/02
CRDT- 2014/03/19 06:00
PHST- 2013/11/27 00:00 [received]
PHST- 2014/01/08 00:00 [accepted]
PHST- 2014/03/19 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2014/11/06 06:00 [medline]
PHST- 2015/02/02 00:00 [pmc-release]
AID - 10.1002/dc.23093 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2014 Apr;42(4):351-62. doi: 10.1002/dc.23093.