PMID- 24641174
OWN - NLM
STAT- MEDLINE
DCOM- 20151005
LR  - 20140409
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 6
IP  - 7
DP  - 2014 Apr 9
TI  - Synthesis of multifunctional Fe(3)O(4)-CdSe/ZnS nanoclusters coated with lipid A 
      toward dendritic cell-based immunotherapy.
PG  - 5297-307
LID - 10.1021/am500661j [doi]
AB  - We demonstrate a novel route to synthesize Fe3O4-CdSe/ZnS multifunctional 
      nanoclusters (MNCs) with excellent optical and magnetic properties and 
      biocompatibility. The successful fabrication of highly fluorescent and magnetic 
      MNCs is achieved via a coupling process based on a partial ligand exchange 
      reaction at the aqueous-organic solution interface. In addition, we show that 
      dendritic cells (DCs), the sentinel of the immune system, can uptake the MNCs 
      without significant change in cell viability. The MNCs uptaken by the DCs can be 
      used for imaging, tracking, and separating the DCs. Furthermore, the MNCs can be 
      loaded with a pathogen-associated molecular pattern, lipid A, via a 
      hydrophobic-hydrophobic interaction. Ex vivo labeling of DCs with the MNC-lipid A 
      complex enhances the DC migration to draining lymph nodes and tumor 
      antigen-specific T cell responses in vivo. Our work may contribute to the 
      development of synthetic routes to various multifunctional nanoclusters and 
      DC-based cancer immunotherapies.
FAU - Jeong, Jinhoo
AU  - Jeong J
AD  - Department of Materials Science and Engineering, Korea University , Seoul 
      136-713, Republic of Korea.
FAU - Kwon, Eun-Kyung
AU  - Kwon EK
FAU - Cheong, Taek-Chin
AU  - Cheong TC
FAU - Park, Heeyeon
AU  - Park H
FAU - Cho, Nam-Hyuk
AU  - Cho NH
FAU - Kim, Woong
AU  - Kim W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140327
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Lipid A)
RN  - 0 (Polymers)
SB  - IM
MH  - Cell Movement
MH  - Dendritic Cells/*chemistry/cytology/immunology
MH  - Humans
MH  - Immunotherapy/*instrumentation/methods
MH  - Lipid A/*chemistry
MH  - Lymph Nodes/immunology
MH  - Magnetics
MH  - Nanostructures/*chemistry
MH  - Polymers/chemical synthesis/*chemistry
MH  - T-Lymphocytes/immunology
EDAT- 2014/03/20 06:00
MHDA- 2015/10/06 06:00
CRDT- 2014/03/20 06:00
PHST- 2014/03/20 06:00 [entrez]
PHST- 2014/03/20 06:00 [pubmed]
PHST- 2015/10/06 06:00 [medline]
AID - 10.1021/am500661j [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2014 Apr 9;6(7):5297-307. doi: 10.1021/am500661j. Epub 
      2014 Mar 27.