PMID- 24641258
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 2212-3946 (Electronic)
IS  - 1574-888X (Linking)
DP  - 2014 Mar 19
TI  - Perfusion Method for Intra-bone Marrow Collection and Stem Cell Transplantation: 
      A Critical Review.
AB  - A bone marrow transplant is a procedure to replace damaged or destroyed bone 
      marrow with healthy bone marrow stem cells. Bone marrow is the soft, fatty tissue 
      inside our bones. Bone marrow transplantation (BMT) is a powerful strategy for 
      the treatment of leukemia, aplastic anemia, congenital immunodeficiency and 
      autoimmune diseases. In humans, bone marrow cells (BMCs) have usually been 
      collected by multiple bone marrow aspirations from the iliac crest. We have 
      established a new "perfusion" method for collecting BMCs with minimal 
      contamination with the peripheral blood using the long bones of cynomolgus 
      monkeys. This method has proven to be a simple and safe method for harvesting 
      BMCs and reduces the risk of acute graft versus host disease in allogeneic BMT. 
      Intra-bone marrow-BMT (IBM-BMT) provides distinct advantages because it recruits 
      donor-derived hematopoietic stem cells and mesenchymal stem cells. IBM-BMT has 
      been shown to currently be the best strategy for allogeneic BMT. Here we review 
      the perfusion method (for harvesting BMCs) and IBM-BMT (for their 
      transplantation) and show that this combination will become a powerful new 
      clinical strategy for allogeneic BMT.
FAU - Korrapati, Narasimhulu
AU  - Korrapati N
FAU - Nanganuru, Harikrishna Yadav
AU  - Nanganuru HY
AD  - Department of Biotechnology National Institute of Technology Warangal 
      Warangal-506004, India. simha7762006@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20140319
PL  - United Arab Emirates
TA  - Curr Stem Cell Res Ther
JT  - Current stem cell research & therapy
JID - 101272517
EDAT- 2014/03/20 06:00
MHDA- 2014/03/20 06:00
CRDT- 2014/03/20 06:00
PHST- 2014/03/11 00:00 [received]
PHST- 2014/03/19 00:00 [accepted]
PHST- 2014/03/20 06:00 [entrez]
PHST- 2014/03/20 06:00 [pubmed]
PHST- 2014/03/20 06:00 [medline]
AID - CSCRT-EPUB-59694 [pii]
PST - aheadofprint
SO  - Curr Stem Cell Res Ther. 2014 Mar 19.