PMID- 24642369
OWN - NLM
STAT- MEDLINE
DCOM- 20141212
LR  - 20140428
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 210
IP  - 6
DP  - 2014 Jun
TI  - Neuroprotective effect of curcumin on hippocampal injury in 6-OHDA-induced 
      Parkinson's disease rat.
PG  - 357-62
LID - S0344-0338(14)00046-6 [pii]
LID - 10.1016/j.prp.2014.02.005 [doi]
AB  - Clinically, Parkinson's disease (PD)-related neuronal lesions commonly occur. The 
      purpose of this study is to investigate potential therapeutic effect of curcumin 
      against hippocampal damage of 6-hydroxydopamine (6-OHDA)-PD rat model. These 
      results showed that curcumin significantly increased the body weight of 
      6-OHDA-impaired rats (P<0.01), and reversed the anhedonia in rats induced by 
      6-OHDA impairment (P<0.01). Meanwhile, behavioral manifestations of 
      curcumin-treated PD rats were effectively ameliorated as shown in open field test 
      (P<0.01). In addition, curcumin increased the contents of monoaminergic 
      neurotransmitters (P<0.01), such as dopamine (DA) and norepinephrine (NE), in 
      hippocampal homogenate through high performance liquid chromatography (HPLC) 
      assay. Curcumin effectively alleviated the 6-OHDA-induced hippocampal damage as 
      observed in hematoxylin-eosin (H&E) staining. Furthermore, curcumin obviously 
      up-regulated hippocampal brain derived neurotrophic factor (BDNF), TrkB, 
      phosphatidylinositide 3-kinases (PI3K) protein expressions, respectively as shown 
      in Western blot analysis. These findings demonstrated that curcumin mediated the 
      neuroprotection against 6-OHDA-induced hippocampus neurons in rats, which the 
      underlying mechanism is involved in activating BDNF/TrkB-dependent pathway for 
      promoting neural regeneration of hippocampal tissue.
CI  - Copyright (c) 2014 Elsevier GmbH. All rights reserved.
FAU - Yang, Jiaqing
AU  - Yang J
AD  - Emergency Neurology, Weifang People's Hospital, Shandong 261041, PR China.
FAU - Song, Shilei
AU  - Song S
AD  - Emergency Neurology, Weifang People's Hospital, Shandong 261041, PR China.
FAU - Li, Jian
AU  - Li J
AD  - Emergency Neurology, Weifang People's Hospital, Shandong 261041, PR China. 
      Electronic address: lijian_hospital@163.com.
FAU - Liang, Tao
AU  - Liang T
AD  - Guangxi Medical University, Nanning 530021, PR China.
LA  - eng
PT  - Journal Article
DEP - 20140223
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Antiparkinson Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - IT942ZTH98 (Curcumin)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Antiparkinson Agents/*pharmacology
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Curcumin/*pharmacology
MH  - Cytoprotection
MH  - Disease Models, Animal
MH  - Dopamine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Hippocampus/*drug effects/metabolism/pathology
MH  - Male
MH  - Nerve Regeneration/drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Norepinephrine/metabolism
MH  - *Oxidopamine
MH  - Parkinsonian Disorders/chemically induced/*drug 
      therapy/metabolism/pathology/psychology
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/metabolism
MH  - Signal Transduction/drug effects
OTO - NOTNLM
OT  - Curcumin
OT  - Hippocampi
OT  - Neural injury
OT  - Neuroprotection
EDAT- 2014/03/20 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/03/20 06:00
PHST- 2013/09/03 00:00 [received]
PHST- 2013/12/25 00:00 [revised]
PHST- 2014/02/06 00:00 [accepted]
PHST- 2014/03/20 06:00 [entrez]
PHST- 2014/03/20 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - S0344-0338(14)00046-6 [pii]
AID - 10.1016/j.prp.2014.02.005 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2014 Jun;210(6):357-62. doi: 10.1016/j.prp.2014.02.005. Epub 
      2014 Feb 23.