PMID- 24643119
OWN - NLM
STAT- MEDLINE
DCOM- 20141211
LR  - 20140422
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 69
IP  - 2
DP  - 2014
TI  - Effects of deep repetitive transcranial magnetic stimulation on brain-derived 
      neurotrophic factor serum concentration in healthy volunteers.
PG  - 112-9
LID - 10.1159/000358088 [doi]
AB  - OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive, 
      safe and efficacious technique for treating various neuropsychiatric disorders, 
      but its underlying mechanisms are poorly understood. A newly developed H-coil 
      allows the stimulation of deeper brain regions. This study is the first to 
      investigate the effects of deep high-frequency rTMS on brain-derived neurotrophic 
      factor (BDNF) serum concentrations in healthy volunteers. We aimed to evaluate 
      the short-term effect of deep rTMS on BDNF serum concentrations. METHODS: This 
      was a double-blind, randomized deep high-frequency rTMS study using an H-coil on 
      a cohort of 13 healthy volunteers (NCT01106365). The following stimulation 
      protocols were applied: 18-Hz stimulation of the left dorsolateral prefrontal 
      cortex (PFC), 5-Hz stimulation of the primary motor cortex (MC) and sham 
      stimulation in random order. Blood samples were obtained before, 30 min after and 
      60 min after each treatment. RESULTS: The BDNF serum concentration decreased 
      significantly after MC and PFC stimulation, but not after sham stimulation. 
      Furthermore, BDNF serum level changes were associated with changes in individual 
      alertness. CONCLUSION: Although BDNF serum concentrations do not necessarily 
      correlate with BDNF levels in the cerebrospinal fluid or the brain, these results 
      indicate an acute biological effect of deep rTMS on BDNF release, and demonstrate 
      that this change correlates with alertness.
FAU - Gaede, Gunnar
AU  - Gaede G
AD  - NeuroCure Clinical Research Center, Charite - Universitatsmedizin Berlin, Berlin, 
      Germany.
FAU - Hellweg, Rainer
AU  - Hellweg R
FAU - Zimmermann, Hanna
AU  - Zimmermann H
FAU - Brandt, Alexander U
AU  - Brandt AU
FAU - Dorr, Jan
AU  - Dorr J
FAU - Bellmann-Strobl, Judith
AU  - Bellmann-Strobl J
FAU - Zangen, Abraham
AU  - Zangen A
FAU - Paul, Friedemann
AU  - Paul F
FAU - Pfueller, Caspar F
AU  - Pfueller CF
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140312
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Arousal/*physiology
MH  - Blood Chemical Analysis
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cohort Studies
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiology
MH  - Prefrontal Cortex/*physiology
MH  - Reaction Time
MH  - Time Factors
MH  - *Transcranial Magnetic Stimulation/methods
MH  - Young Adult
EDAT- 2014/03/20 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/03/20 06:00
PHST- 2013/03/01 00:00 [received]
PHST- 2013/12/16 00:00 [accepted]
PHST- 2014/03/20 06:00 [entrez]
PHST- 2014/03/20 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - 000358088 [pii]
AID - 10.1159/000358088 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2014;69(2):112-9. doi: 10.1159/000358088. Epub 2014 Mar 12.