PMID- 24643502
OWN - NLM
STAT- MEDLINE
DCOM- 20150902
LR  - 20140814
IS  - 1559-0283 (Electronic)
IS  - 1085-9195 (Linking)
VI  - 70
IP  - 1
DP  - 2014 Sep
TI  - Fine-tuning of the cellular signaling pathways by intracellular GTP levels.
PG  - 27-32
LID - 10.1007/s12013-014-9897-4 [doi]
AB  - It has become increasingly evident that among purine nucleotides, guanine based 
      nucleotides specially guanosine-5'-triphosphate (GTP) serve as an important and 
      independent regulatory factors for development and diverse cellular functions 
      such as differentiation, metabolism, proliferation and survival in multiple 
      tissues. In this brief review, it has been provided selective outline related to 
      delicate regulation of signaling pathways by guanosine based nucleotides as 
      intracellular signaling molecules. Although the exact mode of action of theses 
      nucleotides in many biological processes and signaling pathways is still elusive, 
      it has become well clear that intracellular guanosine based nucleotides content 
      rather than adenosine based nucleotides could modulate the intensity and duration 
      of signaling which ultimately impact on cell's fate. It opens an entirely new 
      perspective for developing new and potential therapeutic strategies to combat 
      diseases like cancer, hypoxia, etc.
FAU - Meshkini, Azadeh
AU  - Meshkini A
AD  - Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, 
      Mashhad, Iran, a.meshkini@um.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cell Biochem Biophys
JT  - Cell biochemistry and biophysics
JID - 9701934
RN  - 86-01-1 (Guanosine Triphosphate)
SB  - IM
MH  - Cell Death
MH  - Cell Survival
MH  - Guanosine Triphosphate/*metabolism
MH  - Humans
MH  - Intracellular Space/*metabolism
MH  - *Signal Transduction
EDAT- 2014/03/20 06:00
MHDA- 2015/09/04 06:00
CRDT- 2014/03/20 06:00
PHST- 2014/03/20 06:00 [entrez]
PHST- 2014/03/20 06:00 [pubmed]
PHST- 2015/09/04 06:00 [medline]
AID - 10.1007/s12013-014-9897-4 [doi]
PST - ppublish
SO  - Cell Biochem Biophys. 2014 Sep;70(1):27-32. doi: 10.1007/s12013-014-9897-4.