PMID- 24643852
OWN - NLM
STAT- MEDLINE
DCOM- 20150825
LR  - 20220410
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 272
IP  - 2
DP  - 2015 Feb
TI  - Lymph node ratio is of limited value for the decision-making process in the 
      treatment of patients with laryngeal cancer.
PG  - 453-61
LID - 10.1007/s00405-014-2997-3 [doi]
AB  - The lymph node ratio (LNR) combines two types of information--about the extent of 
      neck dissection and about the extent of the pathological examination of the 
      specimen--and thus represents an interesting variable for risk assessment in 
      patients with head and neck cancer. This retrospective study with data from 
      January 1, 1980, to December 31, 2010, evaluates the utility of the LNR as a 
      potential prognostic predictor in patients with laryngeal squamous cell carcinoma 
      (LSCC). A total of 202 consecutive patients with regionally metastasized LSCC who 
      underwent primary surgery with or without adjuvant treatment were included. The 
      mean follow-up period was 4.4 years. The LNR was calculated as the ratio of 
      positive nodes to the total number of nodes removed during neck dissection. 
      Multivariate analysis was carried out. Peak values as averaged clusters of 
      individual LNRs were registered at three points (LNR 0.05, 0.07, and 0.09). LNR 
      0.09 was a significant prognostic parameter in the Cox regression model (P = 
      0.007). Patients with an LNR > 0.09 had a hazard ratio of 2.065 for a 
      disease-specific survival event in comparison with LNR < 0.09. The most accurate 
      LNR for LSCC is expected to be located in the range of 0.08-0.1. The LNR seems to 
      be of limited value for the decision-making process in the treatment of patients 
      with LSCC, in comparison with other locations. Prospective trials will be 
      required in order to allow evidence-based recommendations for treatment decisions 
      based on the LNR.
FAU - Kunzel, Julian
AU  - Kunzel J
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University of 
      Erlangen-Nuremberg Medical School, Waldstrasse 1, 91054, Erlangen, Germany, 
      julian.kuenzel@gmx.net.
FAU - Mantsopoulos, Konstantinos
AU  - Mantsopoulos K
FAU - Psychogios, Georgios
AU  - Psychogios G
FAU - Agaimy, Abbas
AU  - Agaimy A
FAU - Grundtner, Philipp
AU  - Grundtner P
FAU - Koch, Michael
AU  - Koch M
FAU - Iro, Heinrich
AU  - Iro H
LA  - eng
PT  - Journal Article
DEP - 20140319
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Combined Modality Therapy
MH  - *Decision Support Techniques
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/secondary/*therapy
MH  - Lymph Nodes/*pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neck Dissection
MH  - *Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2014/03/20 06:00
MHDA- 2015/08/26 06:00
CRDT- 2014/03/20 06:00
PHST- 2013/12/23 00:00 [received]
PHST- 2014/03/03 00:00 [accepted]
PHST- 2014/03/20 06:00 [entrez]
PHST- 2014/03/20 06:00 [pubmed]
PHST- 2015/08/26 06:00 [medline]
AID - 10.1007/s00405-014-2997-3 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2015 Feb;272(2):453-61. doi: 
      10.1007/s00405-014-2997-3. Epub 2014 Mar 19.